3 Bion Tablet

100 mg+200 mg+200 mcg
Julphar Bangladesh Ltd.

Pack Size & Price:

50's pack : ৳ 250.00 (Unit Price : ৳ 5.00)

Composition

Each tablet contains-
  • Thiamine Nitrate (Vitamin B1) 100 mg
  • Pyridoxine Nitrate (Vitamin B6) 200 mg
  • Cyanocobalamin (Vitamin B12) 200 mcg.
Each 3 ml ampoule contains-
  • Thiamine Hydrochloride (Vitamin B1) 100 mg
  • Pyridoxine Hydrochloride (Vitamin B6) 100 mg
  • Cyanocobalamin (Vitamin B12) 1000 mcg.

Indications

Vitamin B1, B6 & B12 is indicated for the treatment of B1, B6 and B12 deficiency syndrome. It is also indicated in the treatment of:
  • Diabetic neuropathy 
  • Sciatica
  • Peripheral neuralgia 
  • Facial neuralgia
  • Lumbago
  • Intercostal neuralgia
  • Myalgia
  • Spinal pain

Therapeutic Class

Specific combined vitamin preparations

Pharmacology

Vitamin B1 (Thiamine) forms thiamine pyrophosphate by combining with adenosine triphosphate; essential coenzyme in carbohydrate metabolism.

Vitamin B6 (Pyridoxine) is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.

Vitamin B12 (cobalamin) is a water-soluble vitamin that has a key role in the normal functioning of the brain and nervous system, and the formation of red blood cells. It is one of eight B vitamins. It is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis, fatty acid and amino acid metabolism.

Vitamin B1 (Thiamine), B6 (Pyridoxine) & B12 (Cyanocobalamin) play essential role as co-enzyme for the metabolism of nervous system. Thus this combination normalizes the nerve cell metabolism. This combination supports the regeneration of nerve fibers and myelin sheath by activation of the metabolism and the natural repair mechanism. The combination of these 3 vitamins shows better efficacy than that of the individual components. In addition, Vitamin B1, B6 & B12 promote body's own repair mechanism and work in pain management

Dosage & Administration

Tablets may be administered in a dose of 1 to 3 tablets per day or as directed by the physician. 

Ampoules are preferably injected intramuscularly (deep intragluteal). In severe cases 1 ampoule daily until the acute symptoms subside. For milder cases and follow up therapy 2 to 3 ampoules per week. 

Interaction

No such drug interactions have been reported.

Contraindications

Should not be used in the patients on Levodopa therapy and hypersensitivity to any of the active ingredients.

Side Effects

Generally well tolerated. However, a few allergic reactions may be seen.

Pregnancy & Lactation

Oral tablet form is recommended but injectable preparation is not recommended due to presence of benzyl alcohol.

Precautions

Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. Cyanocobalamin is not a suitable form of Vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.

Overdose Effects

If there is known overdose then treatment is symptomatic and supportive.