Adorex Drop

5 mg/ 1 ml
Ambee Pharmaceuticals Ltd.

Pack Size & Price:

15 ml drop : ৳ 20.07

Indications

Stimulation of gut motility in-
  • Non-ulcer dyspepsia
  • Oesophageal reflux, reflux oesophagitis and gastritis
  • Diabetic gastroparesis
  • Functional dyspepsia
  • Speeding barium transit in follow through radiological studies
Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy

In the prophylactic treatment of migraine

Therapeutic Class

Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs

Pharmacology

Domperidone is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.

Dosage & Administration

Adults: 10 - 20 mg every 4 - 8 hours daily
Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.

Domperidone tablet and suspension should be taken 15 - 30 minutes before a meal.  For acute nausea and vomiting, maximum period of treatment is 12 weeks.

Interaction

Domperidone may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Domperidone on gastrointestinal function.

Contraindications

Domperidone is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.

Side Effects

Domperidone may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.

Pregnancy & Lactation

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.

Use in lactation: Domperidone may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Precautions

Domperidone should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.

Overdose Effects

Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.

Storage Conditions

Store in a cool dry place protected from light. Keep out of reach of children.