Hypromellose

Indications

Ophthalmic Solution: Hypromellose dye drop is indicated in tear deficiency due to:
  • Impaired lacrimal secretion and
  • Functional disorders as a result of topical or systemic diseases or
  • Caused by deficient or incomplete eyelid closure.
Ophthalmic Gel: Hypromellose enriched with Carbomer 980 is a long-acting eye gel for lubricating the surface of the eye for all patients with ocular discomfort. The slight hypotonicity of the gel is rapidly "neutralized" by the slightly hypertonic tear fluid caused by dry eyes.

Pharmacology

Hypromellose is a semisynthetic, inert and viscoelastic polymer used as an ophthalmic lubricant. Hypromellose acts as a lubricant and artificial tear in the symptomatic treatment of dehydration of the cornea and conjunctiva due to impaired lacrimal secretion and functional disorders as a result of topical or systemic diseases, or caused by deficient or incomplete eyelid closure.

Dosage & Administration

Ophthalmic Solution: Therapy of dry eye syndrome requires an individual dosage regimen.
  • The usual dose of 0.3% Hypromellose is 1 drop into the conjunctival sac 3 to 5 times per day or as directed by the physician.
  • The dose of 0.5% Hypromellose will be different for different patients. Follow your doctor's directions.
Ophthalmic Gel: Instill 1 or 2 drops in the conjunctival sac of the affected eye(s), as needed. The frequency of administration depends on the severity of the condition. On average, one drop is administered 1-3 times daily. If needed, Hypromellose may be administered more frequently.

Interaction

Hypromellose can be used in combination with contact lenses. No compatibility study with lens material is available.

Contraindications

Hypersensitivity to this drug or to any ingredient in the formulation or component of the container.

Side Effects

Common side effects are brief blurred vision or a slight stinging sensation on instilling Hypromellose. Hypromellose enriched with Carbomer 980 is very well tolerated by users. However, some cases of burning, stinging, allergic reactions or red eyes after instillation have been reported. Transient blurring of vision after administration has also been reported.

Pregnancy & Lactation

There is no experience regarding the safety of Hypromellose in human pregnancy or lactation. Studies in the pediatric population have not been performed.

Precautions & Warnings

If eye pains, changes in vision, continued redness or irritation of the eye are noticed Hypromellose must be discontinued and a doctor should be consulted. If Hypromellose changes color or becomes cloudy, the product should not be used.

Therapeutic Class

Drugs for Dry eyes

Storage Conditions

Store in a cool dry place, away from light. Keep out of reach of children. Do not touch tip of the tube surface since this may contaminate the gel. After one month of the opening do not use the medicine of tube.