100 ml bottle:
৳ 50.00
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Indications
Xcel is indicated for fever, common cold and influenza, headache, toothache, earache, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum pain, inflammatory pain and post vaccination pain in children. It is also indicated for rheumatic & osteoarthritic pain and stiffness of joints.
Pharmacology
Paracetamol has analgesic and antipyretic properties with weak anti-inflammatory activity. Paracetamol (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Paracetamol is a para aminophenol derivative, has analgesic and antipyretic properties with weak anti-inflammatory activity. Paracetamol is one of the most widely used, safest and fast acting analgesic. It is well tolerated and free from various side effects of aspirin.
Dosage & Administration
Tablet:
- Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.
- Children (6-12 years): ½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day.
- Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours).The tablet must not be crushed.
- Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.
- 3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.
- 1-5 years: 1 -2 teaspoonful 3 to 4 times daily.
- 6-12 years: 2-A teaspoonful 3 to 4 times daily.
- Adults: 4-8 teaspoonful 3 to 4 times daily.
- Children 3-12 months: 60-120 mg,4 times daily.
- Children 1-5 years: 125-250 mg 4 times daily.
- Children 6-12 years: 250-500 mg 4 times daily.
- Adults & children over 12 years: 0.5-1 gm 4 times daily.
- Children Upto 3 months: 0.5 ml (40 mg)
- 4 to 11 months: 1.0 ml (80 mg)
- 7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 dose daily for a maximum of 5 days.
- Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.
- Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.
Interaction
Patients who have taken barbiturates, tricyclic antidepressants and alcohol may show diminished ability to metabolise large doses of Xcel. Alcohol can increase the hepatotoxicity of Xcel overdosage. Chronic ingestion of anticonvulsants or oral steroid contraceptives induce liver enzymes and may prevent attainment of therapeutic Xcel levels by increasing first-pass metabolism or clearance.
Contraindications
It is contraindicated in known hypersensitivity to Paracetamol.
Side Effects
Side effects of Xcel are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.
Pregnancy & Lactation
Epidemiological studies in human pregnancy have shown no ill effects due to Paracetamol used in the recommended dosage, but patients should follow the advice of their doctor regarding its use. Paracetamol is excreted in breast milk, but not in a clinically significant amount. Available published data do not contraindicate breast feeding.
Precautions & Warnings
Care is advised in the administration of Xcel to patients with severe renal or severe hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease. Do not exceed the stated dose. Patients should be advised not to take other Xcel-containing products concurrently. Xcel should only be used by the patient for whom it is prescribed when clearly necessary.
Overdose Effects
Liver damage is possible in adults who have taken 10 g or more of Xcel. Ingestion of 5 g or more of Xcel may lead to liver damage if the patient has following risk factors: If the patient is on long term treatment with Carbamazepine, Phenobarbitone, Phenytoin, Primidone, Rifampicin, St John’s Wort or other drugs that induce liver enzymes, or regularly consumes Ethanol in excess of recommended amounts, or is likely to be Glutathione deplete e.g. eating disorders, cystic fibrosis, HIV infection, starvation, cachexia.
Symptoms: Symptoms of Xcel overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. Immediate treatment is essential in the management of Xcel overdose. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma Xcel concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of Xcel. However, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral Methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit.
Symptoms: Symptoms of Xcel overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. Immediate treatment is essential in the management of Xcel overdose. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma Xcel concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of Xcel. However, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral Methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit.
Therapeutic Class
Non opioid analgesics
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Chemical Structure
| Molecular Formula : | C8H9NO2 |
| Chemical Structure : |  |
Common Questions about Xcel 120 mg/5 ml Suspension
What is Xcel 120 mg/5 ml Suspension?
Xcel 120 mg/5 ml Suspension is a medication that performs its action by obstructing the release of pain and fever chemical messengers.
What are the uses of Xcel 120 mg/5 ml Suspension?
Xcel 120 mg/5 ml Suspension is used for the treatment and prevention of conditions and symptoms of diseases like Post immunization pyrexia, menstrual cramps and fever.
What are the Side Effects of Xcel 120 mg/5 ml Suspension Xcel 120 mg/5 ml Suspension?
Allergic reaction, gastric ulcers, fatigue, anemia, nausea and vomiting are possible side effects.
What are the instructions for storage and disposal Xcel 120 mg/5 ml Suspension?
Xcel 120 mg/5 ml Suspension should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.
Should I use Xcel 120 mg/5 ml Suspension empty stomach, before food or after food?
If you take Xcel 120 mg/5 ml Suspension with the food, the reactions that took place in the body carry-outs in a much effective manner.
How long do I need to use Xcel 120 mg/5 ml Suspension before I see improvement in my conditions?
Xcel 120 mg/5 ml Suspension should be consumed, until the complete eradication of the disease. It is advised to use, till the time directed by your doctor.
Is there any food or drink I need to avoid while taking Xcel 120 mg/5 ml Suspension?
You can follow your normal diet under the usage of Xcel 120 mg/5 ml Suspension.
Will Xcel 120 mg/5 ml Suspension be more effective if taken in more than the recommended dose?
There is no need to take Xcel 120 mg/5 ml Suspension more than its recommended doses.
Can I take other medications along with Xcel 120 mg/5 ml Suspension?
Do not use any OTC for cough, cold, allergy, or pain medication without consulting your doctor or pharmacist. Xcel 120 mg/5 ml Suspension contains many combination of medicines. If you use certain products together you may accidentally use too much of Xcel 120 mg/5 ml Suspension.
Can I take Xcel 120 mg/5 ml Suspension with antibiotics?
There are hundreds of antibiotics used to treat infections, so once you receive your prescription, ask your doctor or pharmacist if you can also take Xcel 120 mg/5 ml Suspension at the same time that you take the antibiotic.
Is Xcel 120 mg/5 ml Suspension an NSAID drug?
No, Xcel 120 mg/5 ml Suspension is not classified as an NSAID (nonsteroidal anti-inflammatory drug). It is classified as a miscellaneous analgesic for mild to moderate pain and fever.
Quick Tips
- Xcel 120 mg/5 ml Suspension should be taken with food or milk to prevent upset stomach.
- Take Xcel 120 mg/5 ml Suspension as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
- Do not take indigestion remedies (antacids) within two hours of taking Xcel 120 mg/5 ml Suspension.
- Avoid consuming alcohol while taking Xcel 120 mg/5 ml Suspension as it can increase your risk of stomach problems.
- Inform your doctor if you have liver disease as your dose may need to be adjusted.
- Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking Xcel 120 mg/5 ml Suspension for long-term treatment.
Pack Image: Xcel 120 mg Suspension