Unit Price:
৳ 60.00
(1 x 10: ৳ 600.00)
Strip Price:
৳ 600.00
Indications
Canarol is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Pharmacology
Canagliflozin is an inhibitor of subtype-2 sodium-glucose co-transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter reduces the reabsorption of glucose from renal tubules, leading to more excretion of glucose in urine.
Dosage & Administration
The recommended starting dose is 100 mg once daily, taken before the first meal of the day. Dose can be increased to 300 mg once daily who have CrCl>60 ml/min or who requires additional glycemic control. No dose adjustment is required for mild renal impairment. For moderate renal impairment (CrCl 45-60 ml/min) Canagliflozin 100 mg is recommended.
Interaction
UGT inducers (e.g. rifampin, phenytoin): Canarol exposure is reduced. Consider increasing dose from 100 mg to 300 mg.
Digoxin: Canarol may slightly increase the concentration of digoxin in the body when both drugs are being taken.
Digoxin: Canarol may slightly increase the concentration of digoxin in the body when both drugs are being taken.
Contraindications
History of serious hypersensitivity reaction to Canagliflozin, severe renal impairment, End Stage Renal Disease (ESRD), or on dialysis patients.
Side Effects
The most common adverse reactions of Canarol are female genital mycotic infections, urinary tract infection and increased urination. Other side effects of Canarol include low blood pressure, increases potassium blood levels (hyperkalemia), low blood glucose and increases Low-Density Lipoprotein (LDL-C).
Pregnancy & Lactation
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. For nursing mother discontinue drug or nursing.
Precautions & Warnings
Not for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis.
Therapeutic Class
Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.