Ridicef Capsule

Ridicef is indicated in-

• Community Acquired Pneumonia,
• Acute Exacerbations of Chronic Bronchitis,
• Acute Maxillary Sinusitis,
• Pharyngitis/Tonsillitis,
• Acute Bacterial Otitis Media and
• Uncomplicated Skin and Skin Structure Infections.

Cefdinir is a semisynthetic third generation oral cephalosporin antibotic. It has a broad spectrum bactericidal activity against a wide range of common pathogens, including b-lactamase producing strains like Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, E. coli, Klebsiella pneumoniae, and Proteus mirabilis. As with other cephalosporins, bactericidal activity of Cefexta results from inhibition of cell wall synthesis.

The total daily dose for all infections is 600 mg. The dosage schedule is given in the following:

Type of infection	Dosage	Duration
Acute Exacerbations of Chronic Bronchitis	300  mg two times daily or 600 mg once daily	5 to 10 days
Pharyngitis/Tonsillitis
Acute Bacterial Otitis Media
Acute Maxillary Sinusitis	300 mg two times daily or 600 mg once daily	10 days
Community Acquired Pneumonia	300mg two times daily	10 days
Uncomplicated Skin and Skin Structure Infections

Powder for Oral Suspension: The total daily dose for all infections is 14 mg/kg body weight up to a maximum dose of 600 mg per day. The dosage schedule of oral suspension for pediatric patients as follows:

Type of infection	Dosage	Duration
Acute Bacterial Otitis Media	7mg/kg two times or 14 mg/kg once daily	5 to 10 days
Phayngitis/Tonsilitis
Acute Maxillary Sinusitis	7mg/kg two times or14 mg/kg once daily	10 days
Uncomplicated Skin and Skin Structure Infections	7mg/kg two times daily	10 days

Direction for Reconstitution of Powder for Suspension: Shake the bottle well so that powder does not clog. Add 40 ml (8 x 5 ml spoonful) boiled and cooled water with the provided 5ml spoon to the bottle. Shake well until all powder is dispersed. Reconstituted suspension should be used within 10 days of preparation if kept at room  temperature or within 14 days if kept in a refrigerator. Shake the bottle well before use.

Antacids: Ridicef should be taken at least 2 hours interval of antacid administration.

Iron supplement: Ridicef should be taken at least 2 hours interval of iron supplement administration.

Probencid: It inhibits the renal excretion of Ridicef.

Cefdinir is contraindicated in patients with known allergy to the cephalosporin class of antibiotics.

Common side effects are Diarrhea, Vaginal moniliasis, Nausea & Vomiting, Headache, Rash etc.

Its pregnancy category is B. But there are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. After administration of single 600 mg doses Cefdinir was not detected in the breast milk.

Ridicef, as with other broad-spectrum antibiotics, should be prescribed with caution in individuals with a history of colitis. In patients with transient or persistent renal insufficiency (creatinine clearance <30 ml/min), the total daily dose of Ridicef should be reduced.

Third generation Cephalosporins

Store at room temperature and protect from light. After reconstitution the suspension can be used within 7 days if kept at room temperature and within 14 days if kept in refrigerator (2-8°C). Always keep the bottle tightly closed.