Trilev-Vet Bolus Tablet
Veterinary
900 mg+600 mg
Unit Price:
৳ 22.57
(20's pack: ৳ 451.43)
Indications
This is a broad spectrum anthelmintic used against helminths in cattle, buffalo, sheep, goat etc. The drug is used for the treatment of acute, sub acute and chronic fascioliasis due to early immature, immature and adult stages of Fasciola hepatica & Fasciola gigantica. It is also used against major parasites of ruminant such as Haemonchus and Ostertagia of the abomasum; Cooperia, Trichostrongylus and Bunostomum of the small intestine; Oesophagustomum, Trichuris of the large intestine & Dictyocaulus spp. of the lungs. It is also successful in treating eye worms (Thelazia) of cattle.
Benefits:
Benefits:
- Eradicates all types of larvae, immature & mature fluke & worms.
- No Embryotoxic or Teratogenic effect.
- Single dose therapy.
- Easy to use, saves time and money.
- Ensures increased body weight and milk production.
- Safe in pregnancy & lactation.
Pharmacology
Levamisole is a cholinergic agent. It stimulates ganglion & depolarizes muscle of the worm. The duel effect causes paralysis of the worms. The paralyzed worms can no more maintain their station in the gut and are consequently flushed out of the host. Triclabendazole is the most recent derivative of Benzimidazoles. It is highly effective against all stages of liver flukes, from 1 day old to adult. Benzimidazoles bind to b-tubulin, a structural protein, and block polymerization of tubulin into microtubules. This damages the integrity & transport functions of cells within the parasite and ultimately kills the parasite.
Dosage & Administration
Administered 7.5 mg per kg body weight or as per the following schedule:
- 10-20 kg: No. of Bolus- 1/4
- 21-40 kg: No. of Bolus- 1/2
- 41-75 kg: No. of Bolus- 1
- 76-150 kg: No. of Bolus- 2
- 151-225 kg: No. of Bolus- 3
- 226-300 kg: No. of Bolus- 4
- 301-375 kg: No. of Bolus- 5
- 376-450 kg: No. of Bolus- 6
Interaction
With medicine: Efficacy may be reduced after using Triclabendazole with Piperazine, Ketoprofen, Meloxicam, Levofloxacin and Pefloxacin.
With food & others: No interaction were found with feed.
With food & others: No interaction were found with feed.
Contraindications
This bolus is contraindicated in animals hypersensitive to active ingredients.
Side Effects
Common side effects: salivation.
Rare side effects: hypersalivation, frothing from mouth, muscle tremor, recumbency, rapid respiration, central nervous system depression etc. may be seen.
Rare side effects: hypersalivation, frothing from mouth, muscle tremor, recumbency, rapid respiration, central nervous system depression etc. may be seen.
Pregnancy & Lactation
In recommended dosage the drug does not have effect on pregnancy. The drug has got no embryotoxic or teratogenic effect.
Precautions & Warnings
Adequate water intake should be maintained during and after therapy.
The safety index of Triclabendazole is about 16 times and the safety index of Levamisole is about 3 times than the recommended dosage.
Withdrawal period: Meat-28 days, Milk-10 days.
The safety index of Triclabendazole is about 16 times and the safety index of Levamisole is about 3 times than the recommended dosage.
Withdrawal period: Meat-28 days, Milk-10 days.
Overdose Effects
Overdosing may cause toxicity in animals especially in calves if the dose rate is not based on their actual body weight or health status. No specific antidote is known, only symptomatic treatment are recommended.
Storage Conditions
Store in a cool & dry place protected from light. Keep out of the reach of children.