Calcium Phosphate [Milk source] + Vitamin D3
Indications
This is indicated for the followings:
- Treatment of osteoporosis, osteomalacia, tetany, hypoparathyroidism & osteogenesis.
- It can also be used as a supplement in case of inadequate intake of Calcium in childhood diet, pregnancy & lactation, rickets & poor absorption during old age.
- In kidney disease and pancreatitis.
- The treatment & prevention of Calcium and Vitamin D3 deficiency.
Composition
Each film-coated tablet contains
- Calcium Phosphate BP 715.00 mg equivalent to Elemental Calcium 250 mg
- Cholecalciferol (Vitamin D3) USP 250 IU
Pharmacology
This is the combination of Calcium Phosphate and Vitamin D3. Calcium is absorbed in the intestine which then passes through the intestine to blood & deposited into bone. Active transport through cell is dependent on Vitamin D3. Vitamin D3 keeps bones healthy by increasing the absorption of Calcium in the intestines. Without Vitamin D3 body will be able to absorb only 10% to 15% of the Calcium from the diet.
Dosage & Administration
Two tablets once or twice daily with plenty of water or food as directed by the physician.
Interaction
- Administering Intravenous Ceftriaxone & Calcium can result in life-threatening damage to the lungs & kidneys. Calcium should not be administered intravenously within 48 hours of intravenous Ceftriaxone.
- Calcium can reduce the absorption of tetracycline & fluoride preparations and minimum 3 hours time should be allowed between ingestion of these medications. Thiazide diuretics reduce the renal excretion of Calcium. Phenytoin, barbiturates & glucocorticoids may induce metabolism of Vitamin D3. Intake of certain foods like spinach, cereals, milk and its derivatives may reduce the intestinal uptake of Calcium.
Contraindications
Increased activity of parathyroid gland, hypercalcemia, constipation, kidney stone & extreme loss of body water are such condition in which calcium intake is contraindicated.
Side Effects
Flatulence, diarrhoea, constipation and allergic reactions etc are rare manifestation. Hypercalcemia due to prolong use has rarely been reported.
Pregnancy & Lactation
This should be given to pregnant & lactating mothers as per recommendation of physician. Toxicity of Calcium & Vitamin D3 was tested on pregnant & nursing females which result excellent.
Precautions & Warnings
In mild hypercalciuria reduction of dose is sufficient to return to normal serum Calcium concentration. Patients with kidney stone or with such previous history should be recommended to increase their fluid intake.
Overdose Effects
In the event of an overdose with Calcium & Vitamin D3, contact with the physicians.
Therapeutic Class
Specific mineral & vitamin combined preparations
Storage Conditions
Store below 30°C. Protect from light & moisture. Keep all medicines out of the reach of children.
