Aloe Vera Gel
Indications
- Inflammation
- Acne
- Psoriasis
- UVB ray exposed skin problems
- Sunburn
- Wound management
- Dry skin
Pharmacology
Aloe vera is a succulent plant with thick, fleshy, serrated, lanceolate-shaped leaves of green-greyish color. Aloe vera inner gel is obtained from the lower leaves of the plant by slicing the leaf open. The gel is clear, odorless and tasteless and is free of leaf skin or yellow parts. More than 75 active ingredients from inner gel of aloe vera have been identified including vitamins, minerals, enzymes, sugars, anthraquinones or phenolic compounds, lignin, saponins, sterols, amino acids and salicylic acid.
Different mechanisms have been proposed for the wound-healing effects of aloe vera gel, which include keeping the wound moist, increasing epithelial cell migration, rapid maturation of collagen and reduction in inflammation.
Mucopolysaccharides of aloe vera helps in binding moisture into the skin. It has been identified that the aloe vera gel containing items improves skin hydration by means of humectant mechanism. Aloe vera gel stimulates fibroblast which produces the collagen and elastin fibers making the skin more elastic and less wrinkled.
It inhibits the cyclooxygenase pathway and reduces prostaglandin E2. Recently, the novel anti-inflammatory compound called C-glycosyl chromone was isolated from gel extracts.
Immunomodulating effects occur via activation of macrophage cells to generate nitric oxide, secrete cytokines and present cell surface markers.
Glutathione peroxides activity, superoxide dismutase enzymes and a phenolic antioxidant were found to be present in aloe vera gel, which may be responsible for these antioxidant effects.
Different mechanisms have been proposed for the wound-healing effects of aloe vera gel, which include keeping the wound moist, increasing epithelial cell migration, rapid maturation of collagen and reduction in inflammation.
Mucopolysaccharides of aloe vera helps in binding moisture into the skin. It has been identified that the aloe vera gel containing items improves skin hydration by means of humectant mechanism. Aloe vera gel stimulates fibroblast which produces the collagen and elastin fibers making the skin more elastic and less wrinkled.
It inhibits the cyclooxygenase pathway and reduces prostaglandin E2. Recently, the novel anti-inflammatory compound called C-glycosyl chromone was isolated from gel extracts.
Immunomodulating effects occur via activation of macrophage cells to generate nitric oxide, secrete cytokines and present cell surface markers.
Glutathione peroxides activity, superoxide dismutase enzymes and a phenolic antioxidant were found to be present in aloe vera gel, which may be responsible for these antioxidant effects.
Dosage & Administration
Apply on affected area 3 times daily or as directed by the Physician.
Interaction
In topical administration aloe vera gel is generally considered as safe. Aloe vera gel might enhance the ability of hydrocortisone to reduce swelling if applied topically. The American Pharmaceutical Association rates aloe vera gel for external use in category 2, meaning that “according to a number of well-designed studies and common use, this substance appears to be relatively effective and safe when used in recommended amounts.
Contraindications
Known allergy against aloe vera; discontinue use if skin irritation develops or worsens.
Side Effects
In general, topical application of aloe vera preparations has been regarded as safe as assessed by the Cosmetic Ingredient Review Expert Panel.
Pregnancy & Lactation
There is no evidence that suggests that topical use of aloe vera gel may cause harm to pregnant/lactating mother, fetus or breast-feeding baby.
Storage Conditions
Store in a cool and dry place, away from light and moisture. Store below 25°C. Keep out of reach of children.
