Silymarin & DL-Alpha Tocopherol
Indications
This preparation is indicated for the treatment and prevention of-
- Liver disease (non-alcoholic & alcoholic)
- Fatty liver (non-alcoholic & alcoholic)
- Hepatitis
- Liver cirrhosis (non-alcoholic & alcoholic)
- Jaundice
- Liver fibrosis
- Drug-induced hepatotoxicity
Composition
Each tablet contains-
- Silymarin (Extracted from Milk Thistle) BP 140 mg
- DL-alpha tocopherol acetate (Vitamin E) USP 200 IU.
Pharmacology
Silymarin, a flavonoid complex of Milk thistle, is the biologically active component. Silymarin is well known hepatoprotective agent. It is prepared with standardized extract of Milk Thistle fruits. Silymarin stimulates RNA polymerase-A, enhances protein synthesis and helps to regenerate and repair liver cell. It prevents toxic and foreign substances from penetrating into the liver cells by stabilizing the outer mem- brane of liver cells. Silymarin also acts by anti-lipid peroxidative, antifibrotic, anti-inflammatory, membrane stabilizing, immunomodulatory and liver regenerating mechanisms. Dl-alpha tocopherol acetate (Vitamin E) is a tocol which is one of the most potent anti- oxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. Vitamin E has powerful antioxidant properties which can provide numerous benefits to the body, and may protect cells from oxidative damage.
Dosage & Administration
1 tablet 2 times daily or as directed by physician.
Interaction
Concomitant use of silymarin and butyrophenones or phenothiazines has resulted in the reduction of lipid peroxidation.
Contraindications
Contraindicated in patient with a known hypersensitivity to silymarin & vitamin E.
Side Effects
Well tolerated in recommended dose. Occasionally a mild laxative effect may observe.
Therapeutic Class
Herbal and Nutraceuticals
Storage Conditions
Store in a cool & dry place, away from light & moisture. Keep out of reach of children.