Clotrimazole (Ear drop)
Indications
Clotrimazole ear drop is indicated for the treatment of fungal infections of the ear.
Description
Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. The primary action of clotrimazole is against dividing and growing organisms. Clotrimazole inhibits ergosterol synthesis, resulting in abnormal cellular permeability. This inhibits fungal growth. It has also antibacterial activity.
Pharmacology
Clotrimazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the production of ergosterol, which is an essential component of fungal cell membranes resulting in increased membrane permeability and leakage of essential constituents of the fungal cells.
Dosage & Administration
Instill 2-3 drops of Clotrimazole Ear Drops in the affected ear two or three times daily. The treatment should be continued for at least two weeks after the disappearance of all signs of infection to prevent re-infection.
Interaction
There have been reports of a heat reaction when this medication used concomitantly with Sofradex drops in the ear.
Contraindications
Individuals who have hypersensitivity to any of its components.
Side Effects
Clotrimazole is generally well tolerated after local application but the few side effects have been reported infrequently like erythema, stinging, edema, pruritus and general irritation.
Pregnancy & Lactation
Clotrimazole is recommended during pregnancy only after first consulting a doctor. Because systemic absorption of clotrimazole following topical application is marginal, there should be no risk for the infant during lactation.
Precautions & Warnings
If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy. Clotrimazole ear drop is not intended for ophthalmic use.
Overdose Effects
In case of accidental oral ingestion, supportive measures should be taken.
Therapeutic Class
Aural Anti-fungal preparations
Storage Conditions
Protect from light, store in cool & dry place. Keep out of the reach of children. Protect from freezing. Do not use more than 4 weeks after opening.
