Penadios Capsule

Penadios 20 mg capsule is indicated for the treatment and prevention of-

• Irregular menstruation
• Premenstrual syndrome such as lower abdominal pain, sleep disturbance, cyclic mastalgia, acne, headache, and mood swing
• Hyperprolactinemia
• Mastodynia

Chaste berry (Vitex agnus castus) is native to Western Asia and Southwestern Europe. Chaste berry is used as a common treatment for gynecological disorders due to its central dopaminergic activity. It has been used widely in Europe for gynecologic conditions such as premenstrual syndrome (PMS), cyclical breast discomfort, menstrual cycle irregularities, and dysfunctional uterine bleeding. Major active constituents of Chaste berry are iridoid glycosides such as agnuside, aucubin and flavonoids such as casticin. Chaste berry acts as a hormonal modulator by increasing progesterone levels with the corresponding reduction in estrogen levels via the corpus luteum hormone effect. It shows central action at the pituitary gland that inhibits the release of follicle-stimulating hormone (FSH), promotes the release of luteinizing hormone (LH), and decreases prolactin secretion by the pituitary gland via dopamine antagonistic effect. It is also used for fibrocystic breast, insufficient lactation, corpus luteum insufficiency, prevention of miscarriage in the first trimester of pregnancy in cases of progesterone insufficiency and acne vulgaris.

Orally 1-2 capsules daily with water or as advised by the physician. Duration of the treatment should be at least 3 months and a repeated course is feasible as advised by the physician.

Contraindicated for the patient with known hypersensitivity to Chaste berry.

Generally well-tolerated in recommended dose. Side effects are very rare occurring in only 1-2% of patients
that may include nausea, rash, headache, hair loss, fatigue, agitation, dry mouth, tachycardia, and increased menstrual flow.

Not recommended for use during pregnancy. No known restriction during lactation.

Herbal and Nutraceuticals

Do not store above 30ºC, protect from light & moisture. Keep out of reach of children.