Albendazole
Veterinary
Indications
It is used as anthelmintic against most nematodes and cestodes. Albendazole is effective against these gastrointestinal parasites: Bunostomum, Chabertia, Cooperia, Haemonchus, Nematodirus, Ostertagia, Strongyloides, Dictyocaulus viviparus, Moniezia expansa, Liver flukes and Paramphistomes. It is also effective against different types of worms, lung flukes and lung nematodes.
Benefits:
Benefits:
- Ideal for multiple helminth viz. round worms, tape worms, lung worms and flukes.
- Proven broad spectrum activity against mature and immature stages of worms.
- Wide safety margin, no side effects.
- In pregnant animals can be used after 1st month of pregnancy.
Pharmacology
Benzimidazoles bind to b-tubulin, which in turn prevents its dimerization with a-tubulin and the polymerization of tubulin oligomers into microtubules. Microtubules are essential structural units of many organelles and are necessary for numerous processes, including protein assembly, and energy metabolism. Mammals also rely on tubulin for cellular metabolism but BZDs have a higher affinity for nematode tubulin at normal body temperature range of mammals.
Dosage & Administration
Cattle & Buffaloes:
- Roundworms, Tapeworms, Lungworms: 7.5 mg/kg
- Liver Flukes: 10 mg/kg
- Roundworms, Tapeworms, Lungworms: 5 mg/kg
- Liver Flukes: 7.5 mg/kg
- Roundworms, Pinworms: 7.5 mg/kg
- Lungworms: 25 (b.i.d.) for 5 days
- Roundworms, Whipworms, Hookworms, Tapeworms, Lungworms, Bladderworms, Liver flukes: 15 mg/kg
Side Effects
In several cases nausea, vomiting may occur.
Precautions & Warnings
Safety index: Wide safety margin than any other group due to greater selective affinity for parasitic b-tubulin than for animal tissues.
Withdrawal period: Meat: 8-14 days, Milk: 3-5 days
Withdrawal period: Meat: 8-14 days, Milk: 3-5 days
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
