Ophthalmic Solution

Mydri Atropine Ophthalmic Solution

5 ml drop: ৳ 30.00
Also available as:


1% Eye drops: As a cycloplegic or mydriatic for refraction or for desired dilatation of the iris or uveal tract during acute infammatory conditions.

0.01% Eye drops: This medication is indicated as a treatment to slow the progression of myopia in children aged from 4 to 14 years. Mydri Mydri Atropine treatment may be initiated in children when myopia progresses.


Atropine 1% eye drops: Each ml sterile eye drops contains Atropine Sulphate BP 10 mg. Preservative: Benzalkonium Chloride 0.01%

Atropine 0.01% eye drops: Each ml sterile eye drops contains Atropine Sulphate USP 0.1 mg. Preservative: Sodium Perborate 0.01%


The exact mode of action of Atropine Sulfate is attributed to the suppression of the progression of myopia. Muscarinic receptors are widely distributed in ocular tissues, with roles in ocular growth and development, as well as accommodation, recognized. Preclinical studies suggest that Atropine Sulfate acts via binding to the muscarinic receptors located on scleral fibroblasts and possibly in the retina, primarily the M1, M3 and M4 subtypes. This results in changes in the activity of cell signaling proteins and enzymes such as MEK-ERK-MAPK and transglutaminases, and possibly dopamine release, causing scleral remodeling or strengthening, leading to a reduction in axial length and vitreous chamber depth and consequently a suppression of myopia progression.

Dosage & Administration

1% Eye drops-
  • For uveitis: One drop three times daily
  • For refraction: One drop in the eyes twice daily for one or two days before examination, and one hour before examination. Pressure should be maintained over lacrimal sac, occluding lacrimal duct for one minute after instillation.
0.01% Eye drops- This paediatric eye drops should be administered as one drop to each eye at night. The maximum benefit of treatment may not be achieved with less than a 2-year continued administration period. To minimize the risk of systemic absorption, gentle pressure should be applied to the tear duct for one minute after application.


Mydri Mydri Atropine should not be used with the following medications, because serious interactions may occur with Anticholinergics, Antiglaucoma agents, Potassium Citrate, Potassium Supplements, Carbachol, Physostigmine or Pilocarpine & CNS medication.


This eye drops is contraindicated in the presence of angle closure glaucoma or where angle closure glaucoma is suspected. If used in glaucoma susceptible patients, an estimation of the depth of the angle of the anterior chamber should be performed prior to the initiation of therapy.

Side Effects

Blurred vision, local irritation, follicular conjunctivitis, vascular congestion, oedema, exudate, contact dermatitis, eczematous dermatitis, photophobia etc.

Pregnancy & Lactation

Atropine Sulphate may be systemically absorbed after ocular administration; however, signifcant efects on the fetus have not been reported. Systemically absorbed Atropine Sulphate is distributed into breast milk in very small amounts. It may cause adverse efects, such as rapid pulse, fever, or dry skin, in nursing infant of mothers using ophthalmic Atropine.

Precautions & Warnings

Mydri Mydri Atropine should not be used in children who have previously had severe systemic reaction to Mydri Mydri Atropine. An increased susceptibility to Mydri Mydri Atropine has been reported in children with Down’s syndrome, spastic paralysis, or brain damage; therefore Mydri Mydri Atropine should be used with great caution in these patients. It is recommended that regular eye health clinical reviews are conducted if long term treatment is planned, including the monitoring of anterior segment development, IOP, retinal health and myopia progression. This eye drops should not be used in children less than 4 years of age.

Overdose Effects

Flush the eye with water and seek emergency medical attention. Symptoms of a atropine ophthalmic overdose include headache, fast heartbeat, dry mouth and skin, unusual drowsiness, and fushing.

Therapeutic Class

Mydriatic and Cycloplegic agents

Storage Conditions

Store below 30°C and dry place, away from light. Keep out of the reach of children, do not touch the tip of dropper bottle since this may contaminate the product. Do not use the eye drops after 1 month of first opening of the dropper.