Eprim Plus 1000 mg (Soft Gelatin Capsule) is a brand of the generic Primrose Oil. It is manufactured by Square Pharmaceuticals Ltd..

Herbal Eprim Plus Soft Gelatin Capsule

1000 mg
Unit Price: ৳ 12.00 (30's pack: ৳ 360.00)
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Indications

Primrose Oil is indicated in:
  • Atopic dermatitis
  • Mastalgia, cyclical
  • Lactation
  • Atopic dermatitis in infants
  • Diabetic neuropathy
  • Dry eyes associated with Sjögren’s syndrome
  • Infant formula fortification
  • Nutritional deficiencies (EFAs)
  • Premenstrual syndrome symptoms
  • Raynaud’s disease
  • Rheumatoid arthritis
  • Seborrhoeic dermatitis (milk crust)
  • Uremic skin symptoms

Therapeutic Class

Herbal and Nutraceuticals

Description

Evening Primrose is a plant native to North America. It was one of the first medicinal plants brought back to Europe by settlers in the 16th century. Evening primrose oil (EPO) has been the subject of hundreds of scientific studies, which led to it becoming one of the most widely used botanical medicines today. EPO is sold in over 30 countries as a dietary supplement, drug or food. In 2000, Evening primrose oil ranked 10 th of all herbal dietary supplements in U.S. food, drug and mass-market retail outlets.

Clinical studies have focused on its use in treating problems associated with essential fatty acid (EFA) deficiency including premenstrual syndrome, atopic eczema, inflammation and diabetic peripheral neuropathy. EPO is relatively high in essential fatty acids (EFAs), particularly gamma-linolenic acid (GLA, 7-10%). Evening primrose oil preparations consist of a clear, golden yellow, fixed oil extracted by cold expression or solvent extraction, from the seeds of Oenothera biennis L., which first occur during the second year of plant growth. Evening primrose oil is a biennial herb, infertile for the first year.

Pharmacology

Improves EFA composition of plasma, erythrocyte, platelet lipids and α−tocopherol levels in non-diabetic persons and Type 1 diabetic patients; increases total fat and EFA content of mother's milk; affects fatty acid composition of serum lipids and adipose tissue in men with low dihomo-gamma-linolenic acid (DGLA) levels; helps maintain normal cellular structures and is the precursor of DGLA, which is the parent of the 1-series prostanoids and as a precursor of arachidonic acid, the parent of the 2-series prostanoids. In vitro: Cytostatic activity on malignant cell lines; suppresses cancer cell proliferation of human osteogenic sarcoma cells.

Evening primrose oil (EPO) supplies gamma linolenic acid (GLA). The bioactivity of EPO is due primarily to its GLA content. By supplying GLA, it bypasses the rate-limiting step in the metabolism of LA. After ingestion of EPO, GLA is rapidly absorbed and then converts directly to DGLA and other prostaglandin precursors. It also acts on the prostanoid pathway.

Dosage & Administration

Primrose oil is a long-term therapy, so immediate results should not be expected. A patient may need to use Primrose oil regularly for up to four months before a clinical response is observed. Primrose oil appears to be safe for long-term use of at least one year.

Internal:
  • A TOPIC DERMATITIS: 4-6 capsules (500 mg) twice daily (40 mg Gamma-Linolenic Acid per capsule).
  • CYCLICAL MASTALGIA: 6 capsules (500 mg) daily (40 mg Gamma-Linolenic Acid per capsule) for 4-6 months.
  • DIABETIC NEUROPATHY: 8-12 capsules (500 mg) daily.
  • LACTATION AID: 4 capsules (500 mg) twice daily, morning and evening.
  • RHEUMATOID ARTHRITIS: 10-20 capsules (500 mg) daily.
  • UREMIC SKIN SYMPTOMS: 2 capsules (500 mg) twice daily (45 mg Gamma-Linolenic Acid per capsule).
NOTE: Primrose oil may be swallowed directly or may be taken with milk, another liquid, or with food. Primrose oil taken with food may minimize any potential gastrointestinal side effects. Concurrent ingestion of the antioxidant vitamin E will protect essential fatty acid from free radical damage and also prevent creation of counterproductive substances. Concurrent ingestion of a daily multiple vitamin may also provide nutritional co-factors (e.g., B6 and magnesium) required for essential fatty acid metabolism.

External:
  • A TOPIC DERMATITIS: Water-in-oil emulsion containing 20% Primrose oil, twice daily, applied topically to affected area for at least four weeks.

Interaction

There are no known drug interactions. Steroids and nonsteroidal anti-inflammatory drugs may potentially interfere with essential fatty acid metabolism.

Contraindications

Previously it was not recommended for patients diagnosed with schizophrenia or those already receiving epileptogenic drugs such as phenothiazines. However, a recently published analysis of clinical trials involving polyunsaturated fatty acids in the treatment of schizophrenia did not indicate a clear therapeutic or adverse effect of evening primrose oil supplements on schizophrenic patients.

Side Effects

Adverse effects are rare at recommended dosages. Overdose may cause loose stool and abdominal pain.

Pregnancy & Lactation

No known restrictions. Non-teratogenic, based on animal studies. LA, GLA, and DGLA are important components of human breast milk, so it is reasonable to assume that evening primrose oil may be taken while nursing. According to World Health Organization (WHO), pregnant or lactating women should get 5% of their total daily caloric intake from EFAs.

Storage Conditions

Store in a cool & dry place, away from direct sunlight.