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Indications

Chlorpheniramine Maleate is indicated in the following indications-
  • Urticaria
  • Sensitivity reactions
  • Angioneurotic edema
  • Vasomotor rhinitis
  • Cough
  • Common cold
  • Motion sickness and
  • Other allergic conditions.

Therapeutic Class

Sedating Anti-histamine

Pharmacology

Chlorpheniramine Maleate is an alkylamine antihistamine. It is one of the most potent histamine H1-receptor blocking agents which is used as a potent antihistamine. This generally causes less sedation than promethazine. Chlorpheniramine Maleate exerts its effects by blocking H1-receptor competitively.

Dosage & Administration

Adult- Usual adult dose is 4 mg every 4-6 hours, maximum 24 mg daily.

Child-
  • 6-12 years: 2 mg every 4-6 hours, maximum 12 mg daily.
  • 2-5 years: 1 mg every 4-6 hours, maximum 6 mg daily.
  • 1-2 years: 1 mg twice daily.
Below 1 year the use of Chlorpheniramine Maleate is not recommended.

Interaction

Chlorphenamine maleate has been reported to be incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium, and meglumine adipiodone.

Contraindications

Chlorpheniramine is contraindicated in patients hypersensitive to this agent, in newborn or premature infants.

Side Effects

Chlorpheniramine is well-tolerated, but sometimes drowsiness, dizziness, muscular weakness, and gastrointestinal upset may occur.

Pregnancy & Lactation

This drug should not be used in lactating mother and in pregnancy especially during the first trimester of pregnancy.

Precautions & Warnings

Chlorpheniramine should be used with caution in patients with glaucoma and prostatic hypertrophy. During therapy with chlorpheniramine, caution should be taken in driving vehicles and operating machinery.

Overdose Effects

CNS depression (including sedation, apnea, CV collapse), CNS stimulation (including insomnia, hallucination, tremors, convulsions), tinnitus, blurred vision, dizziness, ataxia, hypotension. Stimulation and atropine-like signs and symptoms (including dry mouth, fixed dilated pupils, flushing, hyperthermia, Gl symptoms) are more likely in children.

Storage Conditions

Store in a cool (Below 25°C temperature) and dry place protected from light. Keep out of the reach of children.