This medication is used to relieve pain, itching, and discomfort from minor skin irritations such as poison ivy, poison oak, and poison sumac. It also helps to dry the oozing and weeping caused by irritation due to these plants.


Calamine has mild astringent and antipruritic actions. Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations, wounds and haemorrhoids. It also reflects ultraviolet radiation and can be used as a physical sunscreen.


Adult: Apply 3-4 times daily for 3-5 days.


Use this medication on the skin only. Follow all directions on the product package, or use as directed by your doctor. Shake the bottle well before using. Apply the medication with a cotton pad, and allow the medication to dry on the skin. If you are uncertain about any of the information, consult your doctor or pharmacist.


There are no known drug interactions for calamine/ zinc oxide topical.


History of hypersensitivity to any of the components.

Side Effects

A very serious allergic reaction to Calamin M is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Pregnancy & Lactation

Category Not Classified. FDA has not yet classified the drug into a specified pregnancy category.

Precautions & Warnings

For external use only. Not to be used on open wounds or burns.

Use in Special Populations

Pediatrics: Appropriate studies on the relationship of age to the effects of calamine have not been performed in the pediatric population. 

Geriatrics: Appropriate studies on the relationship of age to the effects of calamine have not been performed in the geriatric population.

Therapeutic Class

Local Antipruritic