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Xynor is indicated for Amoebiasis (Intestinal and hepatic), Giardiasis, Trichomoniasis, Bacterial vaginosis, Treatment of susceptible anaerobic infections


Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.

Dosage & Administration

  • Adults: 500 mg twice a day for 5 days.
  • Children: 10-25 mg per kg body weight in two divided doses.
Amoebic dysentery:
  • Adults: 1.5 gm once a day for 3 days.
  • Children: 40 mg per kg body weight, once a day for 3 days.
  • Adults: 1.5 gm once daily for 1-2 days.
  • Children: 40 mg per kg body weight for 2 days.
Trichomoniasis: 1.5 gm once or 500 mg twice a day for 5 days. Sexual partner should also be treated at the same time.

Bacterial vaginosis: 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days.


Like other imidazoles, Xynor has a mild potential to cause disulfiramlike reactions. Concomitant administration of oral anticoagulants may increase the risk of haemorrhage due to diminished hepatic metabolism. Xynor has been reported to decrease the clearance of 5-fluorouracil.


Previous hypersensitivity to Ornidazole and to other nitroimidazoles. Ornidazole is contraindicated in central nervous system disorders, particularly in epilepsy or in peripheral neuropathy.

Side Effects

Side effects of Xynor have been mainly limited to the gastrointestinal tract (nausea, vomiting, epigastric pain) and central nervous system (dizziness, headache, lassitude). Unlike other nitroimidazoles, Xynor does not interact with alcohol, although this requires further study.

Leukopenia has been described occasionally during therapy. Adverse central nervous system (CNS) effects of Xynor have mainly included headache, dizziness, lassitude or somnolence, fatigue and weakness. Adverse CNS effects of Xynor may be less than that happens with metronidazole. Seizures have not been reported with Xynor in studies available to date.

Pregnancy & Lactation

Adequate clinical trials have not been conducted. Ornidazole should be prescribed only if the potential benefit justifies the potential risk to fetus/neonate.

Precautions & Warnings

In patient with ataxia, vertigo, and mental confusion, Xynor should be prescribed with caution. During prolonged treatment with Xynor, blood dyscrasia namely mild leukopenia have been reported rarely. In case leukopenia occurs, the decision to discontinue the therapy should depend upon the gravity of infection.

Use in Special Populations

Renal Impairment Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.

Hepatic Impairment Severe: Double the interval between doses.

Therapeutic Class

Amoebicides, Anti-diarrhoeal Antiprotozoal

Storage Conditions

Store at room temperature and protect from light and moisture.
Pack Image of Xynor 500 mg Tablet Pack Image: Xynor 500 mg Tablet