Indications

It is used to treat skin infections caused by either fungi and/or bacteria, such as-
  • Ringworm
  • Athlete's foot and
  • Infected nappy rash

Composition

Each gram Cream contains-
  • Chlorhexidine Hydrochloride BP 10 mg
  • Nystatin USP 100000 IU equivalent to 20 mg of dry substance (Ph. Eur.)

Pharmacology

Nystatin is a fungistatic and fungicidal antibiotic primarily effective against Candida albicans. Chlorhexidine has activity against a wide range of bacteria. Nystatin is poorly absorbed from the gastrointestinal tract. It is not absorbed through the skin or mucous membranes when applied topically

Dosage & Administration

Route of administration: Topically
Child: Apply 2-3 times a day, continuing for 7 days after lesions have healed.
Adult: Apply 2-3 times a day, continuing for 7 days after lesions have healed. Or as directed by the physician.

Interaction

There are no known drug interactions.

Contraindications

Known hypersensitivity to the active substances, especially in those with a history of possible chlorhexidine-related allergic reactions.

Side Effects

Common side effects: Allergic skin reactions such as dermatitis, pruritus, erythema, eczema, rash and skin irritation. Rare side effects: Severe allergic reactions, leading to a drop in blood pressure and even to unconsciousness.

Pregnancy & Lactation

This cream should be administered with caution during the early months of pregnancy.

Precautions & Warnings

For external use only. Avoid contact with eyes. If sensitivity occurs, or if new infection appears, discontinue use and institute alternative therapy. This cream contains chlorhexidine. Chlorhexidine is known to induce hypersensitivity, including generalized allergic reactions and anaphylactic shock. This cream should not be administered to Anyone with a potential history of an allergic reaction to a chlorhexidine-containing compound.

Overdose Effects

This is poorly absorbed from the gastrointestinal tract. In the event of accidental oral ingestion, routine measures such as gastric lavage should be performed as soon as possible after ingestion.

Therapeutic Class

Chlorhexidine & Chloroxylenol preparations

Storage Conditions

Store below 30°C temperature & dry place, protected from light. Keep out of the reach of children.