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Indications

Gatifloxacin is indicated in the following infections:
  • Acute bacterial exacerbation of chronic bronchitis due to Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, or Staphylococcus aureus.
  • Acute sinusitis due to Streptococcus pneumoniae or Haemophilus influenzae.
  • Community-acquired pneumonia due to Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Staphylococcus aureus, Mycoplasma pneumoniae, Chlamydia pneumoniae ... Read more

Pharmacology

Gatifloxacin is a fluoroquinolone antibacterial which acts by inhibiting DNA synthesis in susceptible organisms via inhibition of both DNA gyrase (essential for bacterial reproduction) and topoisomerase IV (essential during bacterial cell division).

Dosage

  • Acute Bacterial Exacerbation of Chronic Bronchitis: 400 mg 5 days
  • Acute Sinusitis: 400 mg 10 days
  • Community-acquired Pneumonia: 400 mg 7-14 days
  • Uncomplicated Skin and Skin Structure Infections: 400 mg 7-10 days
  • Uncomplicated Urinary Tract Infections: 400 mg Single Dose or 200 mg 3 days
  • Complicated Urinary Tract Infections: 400 mg 7-10 days
  • Acute Pyelonephritis: 400 mg 7-10 days
  • Uncomplicated Urethral Gonnorrhea in Men: 400 mg Single dose

Administration

Gatifloxacin can be administered without regard to food.

Contraindications

Gatifloxacin is contraindicated in patients with a history of hypersensitivity of Gatifloxacin, quinolone antimicrobial agents, or any other components of this product.

Side Effects

Gatifloxacin is generally well tolerated. The most common side effects that can occur while taking this drug are usually mild and include nausea, vomiting, stomach pain, diarrhea, dizziness,and headache .

Pregnancy & Lactation

Pregnancy: Gatifloxacin should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus.

Lactation: It is not known whether Gatifloxacin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when gatifloxacin is administered to a nursing woman.

Precautions & Warnings

Gatifloxacin should be administered with caution in the presence of renal insufficiency.

Use in Special Populations

Renal Impaired patient:
  • Creatinine Clearance 40 mL/min: 400 mg every day.
  • Creatinine Clearance < 40 mL/min: 400 mg 200 mg every day.
Dialysis patients:
  • Hemodialysis: 400 mg 200 mg every day.
  • Continuous peritoneal dialysis: 400 mg 200 mg every day.
Pediatric use: The safety and effectiveness of Gatifloxacinacin in pediatric populations (<18 years of age) have not been established.

Overdose Effects

Gatifloxacin exhibits a low potential for acute toxicity in animal studies. In the event of acute oral overdose, the stomach should be emptied by inducing vomiting or by gastric lavage. The patient should be carefully observed (including ECG monitoring) and given symptomatic and supportive treatment. Adequate hydration should be maintained.

Therapeutic Class

4-Quinolone preparations