Benzocaine + Camphor + Methanol + Phenol

Indications

This is indicated in sore throat, toothaches, gum pain, canker sores

Pharmacology

Benzocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

Camphor is a naturally occurring compound that is used as a major active ingredient of balms and liniments supplied as topical analgesics. Despite its long history of common medical use, the underlying molecular mechanism of camphor action is not understood.

Menthol is topically applied agents widely used for similar purposes, are known to excite and desensitize sensory nerves by acting on two members of transient receptor potential (TRP) channel superfamily: heat-sensitive TRP vanilloid subtype 1 (TRPV1) and cold-sensitive TRP channel M8, respectively.

Phenol is a potent proteolytic agent. Concentrations in the 5% to 7% range dissolve tissue on contact via proteolysis. In high concentrations when injected next to a nerve, phenol produces a chemical neurolysis which is nonselective across nerve fiber size and most prominent on its outer aspect. Local anesthetic effects occur within 5-10 minutes.

Dosage & Administration

Adults: apply to the affected area not more than 3 to 4 times daily

Children 2 years of age and older: apply to the affected area not more than 3 to 4 times daily.

Children under 12 years of age: adult supervision should be given in the use of this product

Interaction

There are no known drug interactions and none well documented.

Contraindications

Do not use this product if you have a history of allergy to local anesthetics such as procaine, butacaine, benzocaine, or other "caine" anesthetics.

Side Effects

Benzocaine are more likely to cause contact sensitization. Slight burning, tingling, or stinging may occur.

Pregnancy & Lactation

Pregnancy Category: Not Classified. FDA has not yet classified the drug into a specified pregnancy category.

Precautions & Warnings

Do not use over deep or puncture wounds, infections, or lacerations. Do not use for more than 7 days. When using this product avoid contact with the eyes, do not exceed recommended dosage. Keep out of reach of children.

Therapeutic Class

Topical Local Anesthetics

Available Brand Names

No brand names available