Sodium Chloride (Intravenous Solution)

Indications

Sodium Chloride is a sterile solution of Sodium Chloride in water for injection. Each 100 ml solution contains Sodium Chloride B.P. 0.9 gm. Isotonic (0.9% w/v) Sodium Chloride infusion is used in sodium and water depletion.

For instance, in the management of metabolic alkalosis, in case of gastro-enteritis, during and after surgery. It may also be used as a priming fluid for haemodialysis procedures. Sodium Chloride 0.9% infusion is often used as diluents for infusion of drug additives etc. It is widely used for sterile irrigation and dilution process.

Dosage

The concentration and dosage of Sodium Chloride solution for intravenous use is determined by several factors including age, weight and clinical condition of the patient. Usually, the adult dose is about 1000 ml of 0.9% injection.

Administration

  • Check infusion set and infusion solution prior to use.
  • Pull moderately to tear off the protective cover of the Eurocap.
  • Hold lightly the Eurocap but not the bottle body.
  • Open the flow regulator fully and hold the giving set on the top white area, but not the memorane venting region.
  • Insert the spike of the administration set to the Eurocap and fit the connector of the administration set firmly to the needle.
  • Gradually allow the fluid to flow down to the needletip and close.
  • Remove the protective cover of the needle.
  • Locate the venpuncture site and clean the site with an antiseptic solution, and then insert the needle.
  • Securely tape the puncture site.
  • Securely tape the wings and tubing
  • Start infusion while adjusting drip speed.

Side Effects

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation, and hypervolemia. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.

Pregnancy & Lactation

Pregnancy Category C. Animal reproductive studies have not been conducted with Sodium Chloride Injection USP 0.9%. It is also not known whether Sodium Chloride Injection USP 0.9% can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Sodium Chloride Injection USP 0.9% should be given to a pregnant woman only if clearly needed.

Precautions & Warnings

Serum electrolyte concentration should be carefully monitored. Sodium Chloride should be administered with caution to patients with congestive heart failure, peripheral or pulmonary oedema, impaired renal function or pre-eclampsia. Care should also be taken when administering Sodium Chloride intravenously to very young or elderly patients. Excessive administration should be avoided as this may result in hypokalaemia. Infusion of fluid should be immediately discontinued if rigor arises for any reason during its application. Do not use if the solution is cloudy, contains particles, or after expiry date.

Therapeutic Class

Intravenous fluid preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.