Vitamin D3 + Vitamin K1 + Vitamin K2
Indications
This combination tablet is indicated in:
- Support for cardiovascular health
- Contribute to normal absorption and utilization of calcium and phosphorous in the body
- Contribute to normal blood clotting
- Contribute to the maintenance of normal bones
Pharmacology
Phylloquinone is often called vitamin K1. Phylloquinone is fat soluble and stable in air and moisture. However, it degrades in sunlight. It is found naturally in a wide variety of green plants. Vitamin K is needed for the post translational modification of certain proteins, mostly required for blood coagulation.
Vitamin K2 is necessary for the activation of osteocalcin, a protein that transports and integrates calcium into bone to ensure a healthy skeleton. Incorporating calcium into the bone matrix means that less calcium is available for harmful deposits in soft body tissues.
Vitamin D3 (Cholecalciferol) is essential for normal bone growth & development and to maintain bone density. It also helps our body to utilize both Calcium & Phosphorus.
The active form of Vitamin D3, Calcitriol, exerts its effect by binding to the Vitamin D receptors (VDRs) which are widely distributed through many body tissues.Vitamin D3 has a half life of about 50 days as it is fat soluble.Vitamin D3 is absorbed in the small intestine and bound to specific a-globulins and transported to the liver where it is metabolised to 25-hydroxy Vitamin D3 (Calcidiol). A second hydroxylation to 1,25-dihydroxy Vitamin D3 (Calcitriol) occurs in the kidney. This metabolite is responsible for the vitamin's ability to increase the absorption of calcium. Non-metabolised Vitamin D3 is stored in tissues such as fat and muscle.Vitamin D3 is eliminated via faeces and urine.
Vitamin K2 is necessary for the activation of osteocalcin, a protein that transports and integrates calcium into bone to ensure a healthy skeleton. Incorporating calcium into the bone matrix means that less calcium is available for harmful deposits in soft body tissues.
Vitamin D3 (Cholecalciferol) is essential for normal bone growth & development and to maintain bone density. It also helps our body to utilize both Calcium & Phosphorus.
The active form of Vitamin D3, Calcitriol, exerts its effect by binding to the Vitamin D receptors (VDRs) which are widely distributed through many body tissues.Vitamin D3 has a half life of about 50 days as it is fat soluble.Vitamin D3 is absorbed in the small intestine and bound to specific a-globulins and transported to the liver where it is metabolised to 25-hydroxy Vitamin D3 (Calcidiol). A second hydroxylation to 1,25-dihydroxy Vitamin D3 (Calcitriol) occurs in the kidney. This metabolite is responsible for the vitamin's ability to increase the absorption of calcium. Non-metabolised Vitamin D3 is stored in tissues such as fat and muscle.Vitamin D3 is eliminated via faeces and urine.
Dosage & Administration
Adults and children over 12 years of age: 1-2 capsule daily or as directed by the physician.
Interaction
Vitamin K antagonizes the effect of coumarin-type anticoagulants. Co-administration of anticonvulsants can impair the action of vitamin K. Cholecalciferol is known to interact with Carbamazepine, Dactinomycin, Diuretics, Fosphenytoin, Miconazole, Phenobarbital, Phenytoin, Primidone.
Contraindications
Contraindicated in patients with known hypersensitivity to any of the ingredients.
Side Effects
Well tolerated in recommended dose.
Pregnancy & Lactation
Vitamin K & D3 is safe in pregnancy & lactation when used as recommended doses.
Therapeutic Class
Herbal and Nutraceuticals
Storage Conditions
Store at a cool & dry place below 30°C temperature, Protect from direct sunlight & moisture. Do not freeze.
