Calcium Gluconate

Indications

Used in the treatment of Calcium Gluconate deficiency states & as a dietary supplement when intake may be inadequate In. Calcium Gluconate is used in-
  • Severe hypoglycemic tetany
  • Hypoparathyroidism
  • Vitamin D-deficiency
  • Osteoporosis and
  • Extreme hypercalcemia

Pharmacology

Calcium gluconate is used to prevent or treat negative calcium balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function.

Dosage & Administration

1-2 ampoules Ca+ Gluconate IM. Daily or every alternate day. Children require 1/2 of adult dose lM injection should be given deep to gluteus medius muscle Using a long needle. This route is not recommended for children.
  • Acute hypocalcemia: 10-20 ml (2.32-4.64 m.mol)/Kg.
  • Body weight Fluoride or lead poisoning: 0.3 ml/Kg Body weights.
  • Neonatal tetany: 0.3 (0.7 m.mo)/Kg body weight.

Interaction

Co-administration of high calcium doses with thiazide diuretics may result in milk-alkali syndrome and hypercalcaemia. May potentiate digoxin toxicity. Decreases effects of calcium-channel blockers. Enhanced absorption with calcitriol (a vitamin D metabolite).

Contraindications

  • In Patients receiving cardiac glycosides
  • In patients with renal failure.
  • In patients with severe hypercalciuria and
  • In patients with hypercalcemia

Side Effects

If Ca+ Gluconate Inj is administrated too rapidly, nausea, vomiting, hot flushes, sweating, hypotension & vasomotor collapse, possibly fatal may occur.

Pregnancy & Lactation

Pregnancy Category C. Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.

Precautions & Warnings

Impaired renal function; cardiac disease; hypercalcaemia-associated diseases, e.g. sarcoidosis; other malignancies. Pregnancy.

Therapeutic Class

Minerals in bone formation, Specific mineral preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.