Sulphamethoxazole + Trimethoprim
Veterinary
Indications
Oral Suspension: Poultry: Mycoplasmosis, Colibacillosis, Salmonellosis (Pullorum, Fowl typhoid), Fowl cholera, Gastroenteritis, CRD, Actinomycosis, Actinobacillosis, Coccidiosis, Infectious polyarthritis, Toxoplasmosis etc.
Bolus: It is used for infections of urinary, respiratory and genital tracts, skin and wound infections and other bacterial infections. It is used for the treatment of actinobacillosis, actinomycosis, coccidiosis, mastitis, canine erlichiasis, oral necrobacillosis, infectious foot rot, necrotic rhinitis, metritis, infectious keratitis, infectious polyarthritis, post abortion, pneumonia, salmonellosis, toxoplasmosis, bronchitis, diarrhoea, bronchopneumonia, etc.
Bolus: It is used for infections of urinary, respiratory and genital tracts, skin and wound infections and other bacterial infections. It is used for the treatment of actinobacillosis, actinomycosis, coccidiosis, mastitis, canine erlichiasis, oral necrobacillosis, infectious foot rot, necrotic rhinitis, metritis, infectious keratitis, infectious polyarthritis, post abortion, pneumonia, salmonellosis, toxoplasmosis, bronchitis, diarrhoea, bronchopneumonia, etc.
Pharmacology
PABA (Para amino benzoic acid) is essential for bacterial growth & multiplication (synthesized by bacteria & supplied from environment). By different enzymatic process PABA is converted into Dihydrofolic acid at first & then Tetrahydrofolic acid. Tetrahydrofolic acid acts as a co-factor for single carbon metabolism & Nucleic acid synthesis. But due to structural similarity of PABA with Sulfonamides Dihydropteridin (essential for dihydrofolic acid synthesis) mistakenly combined with Sulfonamides instead of PABA. As a result Dihydrofolic acid synthesis is prevented. On the other side Trimethoprim prevents the formation of Tetrahydrofolic acid from Dihydrofolic acid. As a result bacterial DNA synthesis is prevented & bacteria are destroyed.
Dosage & Administration
Oral Suspension:
- Poultry: Treatment: 1 ml suspension/1.5 Litre of drinking water for 4-6 days (minimum 15 mg. per Kg body weight). Prevention: 1 ml suspension/3 Litre of drinking water for 3 days.
- Calf: 10 ml suspension/50 kg daily for 5-7 days.
- Cattle & Horse: 30 mg/kg body weight or 1 bolus/40-kg body weight daily.
- Calf, Sheep, Goats: 30mg/kg body weight daily for 5 to 7 days. This can be administered orally by mixing with foods or drinking water.
Contraindications
Should not be used for the animal hypersensitive to active ingredients.
Side Effects
Oral Suspension: It has no side effect at the recommended dose. But prolonged treatment may cause hematological disorders & skin diseases.
Bolus: Frothing and salivation can follow oral dosing in cats. Folate deficiency may occur during prolonged treatment in animals.
Bolus: Frothing and salivation can follow oral dosing in cats. Folate deficiency may occur during prolonged treatment in animals.
Precautions & Warnings
Adequate fluid intake should be ensured during therapy. And Shake the content before use. To be dispensed only by or on the prescription of a registered Veterinary doctor.
Storage Conditions
Store in a cool & dry place, out of reach of children. Protect from light and moisture and keep away from feed.
