Undenatured Type II Collagen + Boswellia Serrata
Indications
This is indicated in-
- Joint pain
- Cartilage formation
- Supports the structure and function of the joint
Pharmacology
Collagen type II (native) is a protein that is part of the cartilage, bone & other types of connective tissues. Type II collagen, like all collagen, is made up of three chains of amino acids: glycine, proline and hydroxyproline, which is known as a triple helix. Undenatured type II chicken collagen is a nutritional supplement derived from chicken sternum cartilage using a patented, low temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activities. Boswellic acids are the major constituents of the gum derived from the plant Boswellia serrata Roxb. The gum resin comprises of ß-boswellic acids as the main triterpenic acid along with 11-keto-ß-boswellic acids and their acetates.
Type II collagen acts as an antigen, causing an autoimmune response that stimulates the production of anti-inflammatory cell-signaling proteins called cytokines. Undenatured collagen type II has unique mechanism of action. Undenatured collagen type II molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of undenatured collagen type II interact with Peyer’s patches (lymphoid tissue) of small intestine to release collagen-specific regulatory T-cells. Collagen- specific regulatory T-cells then migrate to joint areas and prevent release of T-cells.
Preventing the release of T-cells prevent the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inflammatory cytokines resulting in reduction of inflammation, halting the erosion of joint cartilage and promote cartilage rebuilding. Undenatured collagen type II supports joint function, mobility and flexibility and also improves knee extension by up to 10% for better range of motion. It also relieves joint pain due to strenuous exercise. Chicken collagen also contains the chondroitin & glucosamine which help in rebuilding cartilage. The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid & acetyl-11-keto-β-boswellic acid, responsible for inhibition of pro-inflammatory enzymes.
Type II collagen acts as an antigen, causing an autoimmune response that stimulates the production of anti-inflammatory cell-signaling proteins called cytokines. Undenatured collagen type II has unique mechanism of action. Undenatured collagen type II molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of undenatured collagen type II interact with Peyer’s patches (lymphoid tissue) of small intestine to release collagen-specific regulatory T-cells. Collagen- specific regulatory T-cells then migrate to joint areas and prevent release of T-cells.
Preventing the release of T-cells prevent the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inflammatory cytokines resulting in reduction of inflammation, halting the erosion of joint cartilage and promote cartilage rebuilding. Undenatured collagen type II supports joint function, mobility and flexibility and also improves knee extension by up to 10% for better range of motion. It also relieves joint pain due to strenuous exercise. Chicken collagen also contains the chondroitin & glucosamine which help in rebuilding cartilage. The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid & acetyl-11-keto-β-boswellic acid, responsible for inhibition of pro-inflammatory enzymes.
Dosage & Administration
1 capsule daily or as advised by the registered physician.
Contraindications
Contraindicated in patient with known hypersensivity to chicken or egg.
Side Effects
Well tolerated in the recommended dose. Constipation and headache may have occurred at high dose.
Pregnancy & Lactation
Scientific information is limited on the use of Undenatured collagen type II & Boswellia Serrata Extract during pregnancy or lactation.
Therapeutic Class
Herbal and Nutraceuticals, Specific mineral & vitamin combined preparations
Storage Conditions
Store away from light, in a dry and cool place. Store below 30°C. Keep all medicines out of the reach of children. For sale and use only under the prescription of a registered physician.
