Abametapir is a pediculicide indicated for the topical treatment of head lice infestation in patients 6 months of age and older. Abametapir should be used in the context of an overall lice management program:
  • Wash (with hot water) or dry-clean all recently worn clothing, hats, used bedding and towels
  • Wash personal care items such as combs, brushes and hair clips in hot water
  • Use a fine-tooth comb or special nit comb to remove dead lice and nits.


Abametapir (5, 5’-dimethyl 2, 2-bipyridinyl) is a metalloproteinase inhibitor Metalloproteinases have a role in physiological processes critical to egg development and survival of lice.

Dosage & Administration

  • For topical use only. Not for oral, ophthalmic, or intravaginal use.
  • Shake well before use.
  • Apply LYBY to dry hair in an amount sufficient (up to the full content of one bottle) to thoroughly coat the hair and scalp. Avoid contact with eyes.
  • Massage LYBY into the scalp and throughout the hair; leave on the hair and scalp for 10 minutes and then rinse off with warm water.
  • Treatment with LYBY involves a single application. Discard any unused product. Do not flush contents down sink or toilet.


For 2 weeks after Abametapir application, avoid taking drugs that are substrates of CYP3A4, CYP2B6 or CYP1A2. Otherwise, avoid use of Abametapir.

Side Effects

The most common side effects of Abametapir include: Redness of the skin or scalp, rash, burning sensation of the skin, skin irritation, vomiting, eye irritation, itchy scalp, changes in your hair color.

Pregnancy & Lactation

Use in Pregnancy and Lactation: Not established
Use in Children and Adolescents: Below 6 months safety of Abametapir not established.

Precautions & Warnings

Risk of Neonatal Benzyl Alcohol Toxicity: Systemic exposure to benzyl alcohol has been associated with serious adverse reactions and death in neonates and low birth-weight infants. Safety and effectiveness in pediatric patients below the age of 6 months have not been established.

Use is not recommended in pediatric patients under 6 months of age because of the potential for increased systemic absorption.

Risk of Benzyl Alcohol Toxicity from Accidental Ingestion: Administer only under direct supervision of an adult.

Overdose Effects

If accidentally swallowed, advise patients to seek medical advice immediately and to call their Local Poison Control.

Storage Conditions

Store between 2°-8° C & frost free place. Keep away from light. Keep out of the reach of children.

Available Brand Names