L-Glutathione
Indications
Glutathione acts as an important antioxidant in your body. That means it helps combat free radicals, molecules that can damage your body's cells. Glutathione plays a role in many chemical reactions in your body. It also helps detoxify chemicals, including some that your body creates naturally, as well as pollutants and drugs. Your supply of glutathione seems to drop as you get older, possibly because your body can't create as much. Lower glutathione levels seem to go hand-in-hand with poorer health. For instance, lower levels may play a role in many conditions that are more likely to develop in older people. Your glutathione levels may also fall if you have certain conditions, such as:
- Cancer
- HIV/AIDS
- Type 2 diabetes
- Hepatitis
- Parkinson's disease
Pharmacology
It is well known that the gastrointestinal cells, the mitochondria and the efficiency of immune cell function are three major factors in immune function. Glutathione happens to play a role in all three elements. When small intestinal mucosa atrophies, it causes an increase in epithelial permeability and compromised tight junctions, which can lead to translocation of bacteria. This translocation of bacteria is implicated in immune activation and autoimmunity. Studies have shown that this epithelial damage is in part due to the inability to mitigate reactive oxygen species (ROS).
Supplementing with oral glutathione under conditions in which intracellular glutathione status is compromised can restore tissue glutathione and promote ROS metabolism, thereby mitigating tissue atrophy, according to a 2017 study published in the World Journal of Gastroenterology.
The most commonly discussed role of glutathione is in the protection of the mitochondria from free radical damage during the process of ATP production. Glutathione is the master antioxidant to quench the reacted oxygen species produced as byproducts, allowing ATP production without the damaging impact that can occur in an environment lacking adequate antioxidant capacity. Mitochondrial health plays a crucial role in immune function via its influence on the T-cell surveillance activity, pattern recognition receptor function, and any ATPdependent immune functions. Regarding individual immune cells, decreased glutathione levels in various cells, such as T-lymphocytes, are observed in patients with immune challenges and the decreased glutathione levels are considered to contribute to a compromised immune system.
The antioxidant properties of glutathione support healthy immune system function. Intracellular GSH plays a key role in the maintenance and regulation of certain immunological functions, including the activation of lymphocytes and functional activity of natural killer (NK) cells. Within three months of 1,000 mg/day
Setria® glutathione, NK cell cytotoxicity increased more than twofold from baseline.
Supplementing with oral glutathione under conditions in which intracellular glutathione status is compromised can restore tissue glutathione and promote ROS metabolism, thereby mitigating tissue atrophy, according to a 2017 study published in the World Journal of Gastroenterology.
The most commonly discussed role of glutathione is in the protection of the mitochondria from free radical damage during the process of ATP production. Glutathione is the master antioxidant to quench the reacted oxygen species produced as byproducts, allowing ATP production without the damaging impact that can occur in an environment lacking adequate antioxidant capacity. Mitochondrial health plays a crucial role in immune function via its influence on the T-cell surveillance activity, pattern recognition receptor function, and any ATPdependent immune functions. Regarding individual immune cells, decreased glutathione levels in various cells, such as T-lymphocytes, are observed in patients with immune challenges and the decreased glutathione levels are considered to contribute to a compromised immune system.
The antioxidant properties of glutathione support healthy immune system function. Intracellular GSH plays a key role in the maintenance and regulation of certain immunological functions, including the activation of lymphocytes and functional activity of natural killer (NK) cells. Within three months of 1,000 mg/day
Setria® glutathione, NK cell cytotoxicity increased more than twofold from baseline.
Dosage & Administration
According to a 2015 publication in the European Journal of Nutrition, supplementing with glutathione at doses of 250 mg and 1,000 mg a day for six months increased glutathione levels in whole blood, erythrocytes and buccal cells. This was the first long-term, randomized, placebo-controlled trial of oral glutathione supplementation.
Side Effects
Glutathione is possibly safe when used in doses up to 500 mg daily for up to 2 months. There isn't a lot of information available about its possible side effects.
Pregnancy & Lactation
If you are pregnant of nursing, consult your health care professional before taking this product.
Precautions & Warnings
When taken by mouth: Glutathione is possibly safe when used in doses up to 500 mg daily for up to 2 months. There isn't a lot of information available about its possible side effects.
When inhaled: Glutathione is possibly safe. There isn't a lot of information available about its possible side effects.
When applied to the skin: There isn't enough reliable information to know if glutathione is safe. It might cause rash when applied to the skin.
Pregnancy and breast-feeding: There isn't enough reliable information to know if glutathione is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Asthma: Do not inhale glutathione if you have asthma. It can increase some asthma symptoms.
When inhaled: Glutathione is possibly safe. There isn't a lot of information available about its possible side effects.
When applied to the skin: There isn't enough reliable information to know if glutathione is safe. It might cause rash when applied to the skin.
Pregnancy and breast-feeding: There isn't enough reliable information to know if glutathione is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Asthma: Do not inhale glutathione if you have asthma. It can increase some asthma symptoms.
Therapeutic Class
Herbal and Nutraceuticals
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
