Topical antiseptic as first aid to help prevent infection in minor cuts, scrapes and burns
In aqueous solutions Gentian violet (GV) dissociates into positive (GV+)and negative ions (Cl-) that penetrate through the wall and membrane of both gram-positive and gram-negative bacterial cells. The GV+ interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. A similar cell penetration and DNA binding process is thought to take place for fungal cells as well. Because Gentian violet is a mutagen and mitotic poison, cell growth is consequently inhibited. A photodynamic action of gentian violet, apparently mediated by a free-radical mechanism, has recently been described in bacteria and in the protozoan T. cruzi. Evidence also suggests that gentian violet dissipates the bacterial (and mitochondrial) membrane potential by inducing permeability. This is followed by respiratory inhibition. This anti-mitochondrial activity might explain gentian violet's efficacy towards both bacteria and yeast with relatively mild effects on mammalian cells.
Dosage & Administration
Clean the affected area and apply a small amount of this product on the area 1 to 3 times daily. May be covered with a sterile bandage.
There are no known drug interactions and none well documented.
Do not apply to an ulcerative lesion as this may cause tattoing of the skin.
Redness, irritation, swelling or pain persists or increases of if infection occurs.
Pregnancy & Lactation
Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.
Precautions & Warnings
Stop use if the condition persists or gets worse. Do not use longer than 1 week.
Crystal violet/ Gentian violet preparations