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Indications

Mecobal tablet is indicated in-
  • Peripheral neuropathy
  • Diabetic neuropathy
  • Alcoholic neuropathy
  • Drug induced neuropathy
  • Entrapment neuropathy
  • Lumbago
  • Intercostal neuralgia
  • Diabetic retinopathy
  • Multiple sclerosis
  • Vertebral syndrome
  • Parkinson's disease
  • Alzheimar's disease
  • Bell's palsy
Mecobal Injection is indicated in-
  • The treatment of peripheral neuropathies megaloblastic anemia due to vitamin B12 deficiency.

Pharmacology

Mecobalamin is one of the two coenzyme forms of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. It is a cofactor in the enzyme methionine synthase which functions to transfer methyl groups for the regeneration of methionine from homocysteine. It is required for integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis. Mecobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves, promotes axonal transport and has neuroprotective activity.

Dosage & Administration

Tablet: 0.5 mg tablet 3 times daily after meal. The dosage should be adjusted according to age of patient’s and the severity of the symptoms.

Injection:
  • Peripheral Neuropathies: Adult: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. The dose may be adjusted depending on the patient's age and symptoms.
  • Megaloblastic Anemia: Adult: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. After 2 months of medication, the dose should be reduced to a single administration of 1 ampoule at 1 to 3 month intervals for maintenance therapy.
Use in Children: Not Recommended.

Interaction

Absorption of vitamin B12 from the gastrointestinal tract may be reduced by neomycin, aminosalicylic acid, histamine H2-antagonists, omeprazole, and colchicine. Serum concentrations may be decreased by use of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.

Contraindications

Hypersensitivity to Mecobalamin or other components of the formulation.

Side Effects

Dermatologic Effects: Rash; In the event of such symptoms, treatment should be discontinued.

Gastrointestinal Effects: Anorexia, nausea/vomiting and diarrhea.

Neurologic Effects (Central nervous system): Headache.

Others:
  • Anaphylactoid reaction: decrease in blood pressure or dyspnea, may occur. Patients should be carefully observed. In the event of such symptoms, treatment should be discontinued immediately and appropriate measures taken.
  • Hot sensation
  • Diaphoresis
  • Pain/induration at the site of intramuscular injection

Pregnancy & Lactation

There are no data available for mecobalamin to be used in pregnant women & lactating mother. However, since vitamin B12 is distributed into breast milk, The American Academy of Pediatrics considers its use to be usually compatible with breast feeding.

Precautions & Warnings

Mecobal should not be used aimlessly for more than one month unless it is effective. The prolonged use of larger doses of Mecobal is not recommended for patients whose occupation requires the handling of mercury or mercury compounds.

Therapeutic Class

Drugs for Megaloblastic Anemia

Storage Conditions

Store at room temperature. Protect from moisture and light.