Luzent Capsule

20/5 mg capsule is indicated in-

• Age related macular degeneration (AMD)
• Cataracts
• Retinitis pigmentosa

10/2 mg chewable tablet is indicated in-

• Digital Vision Syndrome (Headaohe, Eye Pain & Fatigue)
• Visual Enhancernent
• Cognitive Health Enhancement (Attention / Focus, Memory & Leaming)

Lutein and Zeaxanthin are two important antioxidants belonging to the class of carotenoids called xanthophyll. They are major constitutes of macular pigment, a compound concentrated in the macula region of the retina that is responsible for fine- feature vision. Lutein and Zeaxanthin serve important antioxidant functions, including deactivating free radicals and filtering harmful blue light that can otherwise lead to oxidative stress, inflammation, and damage to the visual system. Lutein and Zeaxanthin protect healthy cells from oxidative stress, inflammation and free radical damage.

Many electronic devices (mobile, tab etc.) emit significant amounts of high-energy, blue light which can be absorbed by the photosensitive retinal ganglion cells (pRCGs), and create localized oxidative stress and damage. Laboratory studies conducted with rats and humans show that extended exposure to blue light can actually accelerate rates of retinal cell death, inhibit melatonin, and lead to disturbances in the sleep-wake cycle.

Lutein and zeaxanthin are believed to combat light-induced damage by absorbing incoming wavelengths of damaging light before they can form reactive oxygen species. Lutein and Zeaxanthin can help protect retinal cells by physically and chemically "quenching" these unstable molecules.

Lutein and Zeaxanthin in the form of nutritional supplements can also improve children's carotenoid status. Studies show that Lutein and Zeaxanthin supplements are safe for children as young as preterm infants, and can effectively increase plasma levels in infants and children. A number of studies show that, in addition to visual benefits, supplementation with Lutein and Zeaxanthin can enhance cognitive performance during childhood

In studies conducted with school-aged children (aged 7-10 years), researchers found that children with high macular pigment ocular density (MPOD) made the least errors on a memory task, and performed the best on reading, math, written language, and achievement tests. Conversely, children in these studies with low MPOD (i.e., low levels of lutein and zeaxanthin in their brain) performed less well. Another study of 10 mg Lutein and 2 mg Zeaxanthin for 180 days showed significant increases in serum lutein levels, reduced eye strain (pain, headache) and fatigue, and improved cognitive performance (focus, episodic memory and learning, visuospatial working memory)

1 capsule or 1 chewable tablet daily or as advised by the physician.

Certain drugs have been reported to decrease absorption of Lutein and Zeaxanthin. Proton-pump inhibitors and lipid lowering drugs may reduce the absorption of carotenoids.

No toxicities have been reported in the scientific literature for Lutein and Zeaxanthin at doses up to 40 mg for 2 months.

No side effects have been reported. Lutein is recognized as "Generally, Recognized as Safe (GRAS)" by FDA. No adverse effects were reported after the supplementation of dietary lutein up to 20 mg/day for 48 weeks, 30 mg/day for 120 days and 40 mg/day for more than 8 weeks. Ames testing has demonstrated an absence of any mutagenic effects for purified Lutein and Zeaxanthin.

Studies on Lutein and Zeaxanthin in pregnant and nursing women have not been conducted.

Herbal and Nutraceuticals

Store in a cool and dry place, away from light and moisture. Keep out of reach of children.