Dirovet Bolus Tablet

Metronidazole is a member of the imidazole class of antibacterial drug and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of Metronidazole is reduced by anaerobes metabolically. Studies have demonstrated that the reduced form of this drug interacts with DNA and gives bactericidal action of Metronidazole.

Bolus Tablet-
Large animal:

• Orally: 40-50 mg/kg body weight (i.e., 1 bolus per 40-50 kg body weight) for 5-7 days.
• Intra-uterine: 4 bolus directly or powdered for douche per 100 kg body weight.

Poultry:

• 1 bolus/3-6 litre drinking water for 4-6 days.
• Or as directed by the Registered Veterinary Doctor.

Powder for Solution-

• Poultry: 1 g/2-3 L drinking water daily for 5 days.
• Pigeon: 20 mg/kg once daily for 5 days or 50 mg/kg on alternate days for 3 treatments.
• Livestock: 4 g/25 kg body weight daily for 5-7 days. Or, as directed by the veterinary physician.

Dirovet bolus is reported to elevate prothrombin time in animals on warfarin or other coumarin anticoagulants. Cimetidine can interfere with the liver's ability to break down this bolus and the dose may have to be reduced. Phenobarbital and phenytoin may increase the metabolism of this bolus.

The drug should not be used in animals hypersensitive to active ingredients.

Usually salivation, vomiting, decreased appetite, gastro-intestinal upset etc may occur.

Metronidazole bolus should be avoided in pregnant animals, especially in the first trimester and should not be used in lactating animals.

This bolus should not be used in young puppies and kittens. This bolus should be avoided or used with caution, at reduced doses, in animals with kidney or liver disease.

Protect from light, store in a cool and dry place. Keep out of reach of children.