Unit Price:
৳ 10.00
(3 x 10: ৳ 300.00)
Strip Price:
৳ 100.00
Indications
Neureliv is indicated for the improvement of subjective symptoms (numbness and pain), abnormality of vibration sense and abnormal change in heartbeat associated with diabetic peripheral neuropathy (when high glycohemoglobin value is noted).
Pharmacology
Epalrestat specifically inhibits aldose reductase and accumulation of sorbitol in the nerve; thereby improves subjective symptoms and nerve dysfunction in patients with diabetic peripheral neuropathy.
Dosage & Administration
The usual adult dose is 1 tablet (50 mg) three times daily before each meal. The dosage may be adjusted according to the patient's age and symptoms.
Interaction
There are no known drug interactions and none well documented.
Contraindications
The drug is contraindicated for patients with known hypersensitivity to epalrestat.
Side Effects
Major adverse reactions are hepatic function abnormalities and thrombocytopenia. In cases of hepatic abnormalities drug should be discontinued immediately and appropriate measures should be taken. Other reactions may be malaise, headache, abdominal pain, nausea, hypersensitivity reaction etc.
Pregnancy & Lactation
The safety of epalrestat in pregnant women has not been established. The drug may be used in pregnant women or in women who may possibly be pregnant only if expected therapeutic benefits outweigh the possible risks associated with the treatment. Breast-feeding should be avoided during administration of epalrestat.
Precautions & Warnings
The administration of Neureliv should be considered to patients showing high glycohemoglobin values even after fundamental therapies for diabetes mellitus such as diet therapy, exercise therapy and treatment with an oral hypoglycemic agent, insulin etc. The efficacy of Neureliv has not been established in patients with diabetic peripheral neuropathy with irreversible organic changes. The patient should be carefully monitored during the administration of Neureliv. When the efficacy of Neureliv is not observed even after 12 weeks of administration, other appropriate therapies should be taken.
Therapeutic Class
Aldose reductase inhibitor
Storage Conditions
Do not store above 30°C temperature. Keep away from light and wet place. Keep out of reach of children.