Unit Price: ৳ 3.00 (5 x 10: ৳ 150.00)
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Indications

Venterol is indicated for
  • Bronchial asthma,
  • Chronic bronchitis,
  • Emphysema &
  • Other lung diseases where bronchospasm is a complicating factor.

Pharmacology

Bambuterol, a prodrug of terbutaline, is a long acting ß2 adrenergic receptor agonist used in the treatment of asthma. Bambuterol is an adrenergic ß2 receptor agonist which predominantly stimulates ß2 receptor, thus producing relaxation of bronchial smooth muscle, inhibition of release of endogenous spasmogens, inhibition of edema caused by endogenous mediators & increased mucocilliary clearance.

Dosage & Administration

Children 2-5 years: The recommended normal dose 10 mg (10 ml syrup).

Children 6-12 years: The recommended normal dose 10 mg (10 ml syrup). The dose may be increased to 20 mg.

Adult: The recommended initial dose 10 mg. The dose may be increased to 20 mg after 1-2 weeks depending on the clinical effect.

Interaction

Succinylcholin, MAOIs (monoamine oxidase inhibitors), ß2-blockers, corticosteroids, diuretics, muscle relaxants, sympathomimetic xanthine derivatives.

Contraindications

Hepatic impairment, liver cirrhosis or severely impaired liver function.

Side Effects

Fatigue, nausea, palpitation, headache, dizziness & tremor.

Pregnancy & Lactation

Although no teratogenic effects have been observed in animal after administration of bambuterol, caution is recommended during first trimester of pregnancy. It is not known whether bambuterol or intermediary metabolites pass over to breast milk, so caution is recommended if bambuterol is administered to patients who are breast feeding. Terbutalin passes over to breast milk but an influence on the child is unlikely with therapeutic doses. Transient hypoglycemia has been reported in new born pre-term infants after maternal ß2 agonist treatment.

Precautions & Warnings

Dose should be reduced in patients with severely impaired renal function, patiensts with genetic deficiencies of plasma cholineterase, patient with severe ischemic heart disease.

Overdose Effects

No case of bambuterol overdosage has yet been reported in human. It is likely that overdosing would result in high levels of terbutaline & therefore the same symptoms & signs may include: headache, anxiety, tremor, nausea, tonic muscle cramps, palpitations, tachycardia & cardiac arrythmias. A fall in blood pressure sometimes occurs after terbutaline overdosage.

Laboratory findings: hyperglycaemia and lactacidosis sometimes occur. High doses of ß2-agonists may
cause hypokalemia as a result of redistribution of potassium.

Therapeutic Class

Short-acting selective & β2-adrenoceptor stimulants

Storage Conditions

Keep away from light, store in a cool and dry place. Keep out of reach of children.