Unit Price:
৳ 55.00
(2 x 10: ৳ 1,100.00)
Strip Price:
৳ 550.00
Indications
Adults: Ornical is indicated in conjunction with a mildly hypocaloric diet for the treatment of obese patients with a body mass index (BMI)>30 kg/m2 and overweight patients (BMI >28 kg/m2 ) with associated risk factors such as type II diabetes, hyperlipidemia and hypertension. Treatment with Ornical should be discontinued after 12 weeks in patients who have not lost at least 5% of their body weight as measured at the start of drug therapy.
Adolescents (12 years & older): Obese adolescents should be treated with Ornical only if an adequate reduction of body weight cannot be achieved by means of diet & increased physical activity. Treatment with Ornical should be considered in particular if complications of obesity are present.
Adolescents (12 years & older): Obese adolescents should be treated with Ornical only if an adequate reduction of body weight cannot be achieved by means of diet & increased physical activity. Treatment with Ornical should be considered in particular if complications of obesity are present.
Pharmacology
Orlistat is a potent, specific and long-acting lipase inhibitor. It exerts its therapeutic activity in the lumen of the stomach and upper small intestine by forming a covalent bond with the active serine site of gastric and pancreatic lipases. The inactivated enzyme is thus rendered unable to hydrolyze dietary fats in the form of triglycerides into absorbable free fatty acids and monoglycerides. As undigested triglycerides can not be absorbed, a caloric deficit arises which has a positive effect on weight control. Systemic absorption of orlistat is therefore not needed for the activity. At the recommended therapeutic dose of 120 mg three times a day, orlistat inhibit dietary fat absorption by approximately 30%.
Dosage & Administration
The recommended dose of Orlistat is one 120 mg capsule to be taken immediately before, during or up to one hour after each main meal. If a meal is missed or contains no fat the dose of Orlistat should be omitted. Doses of Orlistat above 120 mg three times daily have not been shown to provide additional benefits. The effect of Orlistat results in an increase in fecal fat 24-48 hours after dosing. Upon discontinuation of therapy, fecal fat content usually returns to pretreatment levels within 48-72 hours.
The safety & efficacy of Orlistat were investigated in clinical studies lasting up to 4 years. The recommended dose of Orlistat for adolescents is as same as adults.
Special dosage instruction: The tolerability and efficacy of Orlistat have not been studied in elderly patients, or patients with hepatic and/ or renal impairments.
The safety & efficacy of Orlistat were investigated in clinical studies lasting up to 4 years. The recommended dose of Orlistat for adolescents is as same as adults.
Special dosage instruction: The tolerability and efficacy of Orlistat have not been studied in elderly patients, or patients with hepatic and/ or renal impairments.
Interaction
Reduction in cyclosporine plasma levels when Ornical was coadministered with cyclosporine. Ornical inhibited absorption of a vitamin E acetate supplement. The effect of Ornical on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known. Hypothyroidism has been reported in patients treated concomitantly with Ornical and levothyroxine. Patients treated concomitantly with Ornical and levothyroxine should be monitored for changes in thyroid function. Administer levothyroxine and Ornical at least 4 hours apart. Vitamin K absorption may be decreased with Ornical. Patients on chronic stable doses of warfarin who are prescribed Ornical should be monitored closely for changes in coagulation parameters. Convulsions have been reported in patients treated concomitantly with Ornical and antiepileptic drugs. Patients should be monitored for possible changes in the frequency and/or severity of convulsions.
Contraindications
Orlistat is contraindicated in patients with chronic malabsorption syndrome, in patients with cholestasis and in patients who are hypersensitive to orlistat or to any of the other ingredients of the capsules.
Side Effects
Common: Undesirable effects of Ornical are largely gastrointestinal in nature. Common gastrointestinal side effects are oily spotting from the rectum, flatulence, fecal urgency, oily or fatty stool, abdominal discomfort etc.
Rare: Influenza, anxiety. headache, fatigue etc may rarely occur in some patients. Rare cases of hypersensitivity have been reported. Main clinical symptoms are pruritus, exanthema, urticaria, angioedema and anaphylaxis.
Rare: Influenza, anxiety. headache, fatigue etc may rarely occur in some patients. Rare cases of hypersensitivity have been reported. Main clinical symptoms are pruritus, exanthema, urticaria, angioedema and anaphylaxis.
Pregnancy & Lactation
Pregnancy: Orlistat is Pregnancy Category X drug. Orlistat is contraindicated during pregnancy, because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. A minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese, due to the obligatory weight gain that occurs in maternal tissues during pregnancy. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard of maternal weight loss to the fetus.
Lactation: It is not known if Orlistat is present in human milk. Caution should be exercised when Orlistat is administered to a nursing woman.
Precautions & Warnings
Organic causes of obesity (e.g. hypothyroidism) should be excluded before prescribing Ornical. Ornical and cyclosporine should not be coadministered. Cyclosporine should be taken at least 2 hours before or after Ornical in patients taking both drugs. Cyclosporine level should be measured and frequently monitored.
In clinical trial, the decrease in body weight with Ornical therapy was less in type II diabetic patients than in non-diabetic patients. Antidiabetic drug treatment should be closely monitored during Ornical therapy. Because of the improvement in glycemic control, the dose of oral antidiabetics or of insulin may need to be adjusted.
Patients should be advised to adhere to the dietary recommendations. The probability of occurrence of gastrointestinal side effects may increase when Ornical is taken with a fatty meal. The daily intake of fat should be distributed between three main meals. Patients should be strongly encouraged to take a multivitamin supplement that contains fat soluble vitamins to ensure adequate nutrition because Ornical has been shown to reduce the absorption of some fat soluble vitamins & beta-carotene. In addition, the levels of vitamin D & beta carotene may be low in obese patients compared with non-obese patients.
In clinical trial, the decrease in body weight with Ornical therapy was less in type II diabetic patients than in non-diabetic patients. Antidiabetic drug treatment should be closely monitored during Ornical therapy. Because of the improvement in glycemic control, the dose of oral antidiabetics or of insulin may need to be adjusted.
Patients should be advised to adhere to the dietary recommendations. The probability of occurrence of gastrointestinal side effects may increase when Ornical is taken with a fatty meal. The daily intake of fat should be distributed between three main meals. Patients should be strongly encouraged to take a multivitamin supplement that contains fat soluble vitamins to ensure adequate nutrition because Ornical has been shown to reduce the absorption of some fat soluble vitamins & beta-carotene. In addition, the levels of vitamin D & beta carotene may be low in obese patients compared with non-obese patients.
Overdose Effects
Single doses of 800 mg Ornical and multiple doses of up to 400 mg three times a day for 15 days have been studied in normal-weight and obese subjects without significant adverse findings. Should a significant overdose of Ornical occur, it is recommended that the patient be observed for 24 hours. Based on human and animal studies, systemic effects attributable to the lipase-inhibiting properties of Ornical should be rapidly reversible.
Therapeutic Class
Appetite suppressant drugs/Anti-obesity drugs
Storage Conditions
Store in cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.
Pack Image: Ornical 120 mg Capsule