Filfresh Tablet

Filfresh is a hormone secreted by the pineal gland in the brain that helps regulate other hormones and maintains the body's circadian rhythm. It is involved in photic regulations of various kinds, including adaptation to light intensity, daily changes of light and darkness, and seasonal changes of photoperiod lengths. Darkness stimulates the production of Filfresh while light suppresses its activity. Jet lag, shift work, and poor vision can disrupt Filfresh cycles. Filfresh helps control the timing and release of female reproductive hormones. Many researchers also believe that Filfresh levels are related to the aging process. In addition to its hormonal actions, Filfresh has strong antioxidant effects. It also helps strengthen the immune system.

After administration, melatonin binds with its receptors. Two types of melatonin receptor subtypes - MT1 & MT2 have been identified in humans. Melatonin receptors are found in the brain and some peripheral organs. The MT1 subtype is present in the pars tuberalis of the pituitary gland and the suprachiasmatic nuclei of the hypothalamus. The MT2 subtype is mainly present in the retina. Increased level of Melatonin initiates neural & endocrine signals to optimize the levels of neurotransmitters e.g. increased serotonin, increased GABA & decreased dopamine, which induces & sustains sleep, as well as, maintains the body's circadian rhythm.

Adult:
Insomnia: 3-6 mg one hour before bedtime

Jet lag:

• 0.50 to 5 mg one hour prior to bedtime at final destination or, 1 to 5 mg 1 hour before bedtime for 2 days prior to departure and for 2 to 3 days upon arrival at final destination.
• Eastbound travel- Take a preflight early evening treatment followed by treatment at bedtime for 4 days after arrival.
• Westbound travel- Take for 4 days at bedtime when in the new time zone.

Sarcoidosis: 20 mg per day for 4 to 12 months.

Depression: 0.125 mg twice in the late afternoon, each dose 4 hours apart.

Difficulty falling asleep: 5 mg 3 to 4 hours before an imposed sleep period over a 4-weeks period.

Children (6 months to 14 years of age): For sleep disorders 0.30 mg/day

Antidepressant Medications: Filfresh reduces the antidepressant effects of desipramine and fluoxetine. In addition, fluoxetine leads to measurable depletion of Filfresh in people.

Antipsychotic Medications: People with schizophrenia and tardive dyskinesia taking antipsychotic medications with Filfresh has significantly reduced mouth movements compared to those who did not take the supplements.

Benzodiazepines: The combination of Filfresh and triazolam improves sleep quality. In addition, there have been a few reports suggesting that Filfresh supplements may help individuals stop using long-term benzodiazepine therapy.

Blood Pressure Medications: Filfresh may reduce the effectiveness of blood pressure medications like methoxamine and clonidine. In addition, calcium channel blockers (such as nifedipine, verapamil, diltiazem, amlodipine, nimodipine, felodipine, nisoldipine, and bepridil) may decrease Filfresh levels. The use of beta-blockers (propranolol, acebutolol, atenolol, labetalol, metoprolol, pindolol, nadolol, sotalol, and timolol) may reduce Filfresh production in the body.

Blood-Thinning Medications, Anticoagulants: Filfresh may increase the risk of bleeding from anticoagulant medications such as warfarin.

Interleukin-2: In one study of 80 cancer patients, the use of Filfresh in conjunction with interleukin-2 led to more tumor regression and better survival rates than treatment with interleukin-2 alone.

Nonsteroidal Anti-inflammatory Drugs (NSAIDs): NSAIDs such as ibuprofen may reduce the levels of Filfresh in the blood.

Steroids and Immunosuppressant Medications: People should not take Filfresh with corticosteroids or other medications used to suppress the immune system because the supplement may cause them to be ineffective.

Tamoxifen: Preliminary research suggests that the combination of tamoxifen (a chemotherapy drug) and Filfresh may benefit certain patients with breast and other cancers.

Other Substances: Caffeine, tobacco, and alcohol can all diminish levels of Filfresh in the body while cocaine and amphetamines may increase Filfresh production.

Melatonin should not be used by patients who have autoimmune diseases.

Possible adverse effects include headache and depression. Drowsiness may be experienced within 30 minutes after taking Filfresh and may persist for 1 hour and thus may affect driving skills.

Information regarding safety and efficacy in pregnancy and lactation is not available.

Caffeine and fluvoxamine may increase the effects of Filfresh, while Filfresh may decrease the antihypertensive effect of nifedipine.

There is little or no evidence of any major toxicities with Filfresh,even at high doses.

Hormone preparations for other uses, Oral nutritional preparations

Store below 30°C. Keep away from light. Keep all the medicine out of reach of children.