Acyclovir (Ophthalmic)

Prescribing Information (Research Brand)

Indications

Acyclovir eye ointment is indicated for treatment of Herpes Simplex Keratitis.

Therapeutic Class

Ophthalmic Anti-viral Products

Pharmacology

Acyclovir is a synthetic purine neucleotide analogue, which acts against human herpes viruses. The enzyme thymidine kinase (TK)encoded by HSV, VZV and EBV converts acyclovir into acyclovir monophosphate, a neucleotide analogue, which is further converted to diphosphate and triphosphate by cellular enzymes. Acyclovir triphosphate interferes with DNA polymerase and inhibits viral DNA replication with resultant chain termination following its incorporation into the growing viral DNA chain.

Dosage & Administration

Apply ointment into lower conjunctival sac five times daily at 4 hours interval; continue for minimum 3 days after healing.

Interaction

Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects with drugs that affect renal physiology (e.g. ciclosporin, tacrolimus)

Contraindications

It is contraindicated to the patients with known hypersensitivity to acyclovir.

Side Effects

Transient mild stinging immediately following application may occur in a small proportion of patients. Local irritation and inflammation such as blepharitis and conjunctivitis have also been reported.

Pregnancy & Lactation

The use of Acyclovir sterile eye ointment should be considered only when the potential benefits outweigh the possibility of unknown risk.

Precautions

Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration.