Jogaraj Guggulu
Indications
Jogaraj Guggulu is indicated in-
- Rheumatoid arthritis
- Osteoarthritis
- Neuralgias
- Myalgias
- Spondylitis
- Backaches
- Joint pain/ Arthralgia
- Joint stiffness
Composition
Each capsule contains Plumbago zeylanicum 18 mg, Piper longum(Root) 09 mg, Trachyspermum ammi 09 mg, Nigella sativa 09 mg, Cuminum cyminum 09 mg, Cedrus deodara 09 mg, Apium graveolans 09 mg, Piper chaba 09 mg, Elletaria cardamomum 09 mg, Rock salt 09 mg, Saussurea lappa 09 mg, Vanda roxburghii 09 mg, Tribulus terrestris 09 mg, Corriendum sativum 09 mg, Terminalia chebula 09 mg, Emblica officinalis 09 mg, Terminalia belerica 09 mg, Cyperus rotandus 09 mg, Zingiber officinale 09 mg, Piper longum(Seed) 09 mg, Piper nigrum 09 mg, Cinnamomum zeylanicum 09 mg, Vetiberia zizanoid 09 mg, Abies webbiana 09 mg, Cinnamomum tamala 09 mg, Yobkhar 09 mg, Ebmlica ribes 09 mg & Commiphora mukul (Guggulu) 250 mg extract.
Pharmacology
Jogaraj-guggulu is a right preparation of different herbs, which is therapeutically effective in rheumatoid disorder.The phytochemical constituents present in the herbs used for the preparation of Jogaraj-guggulu possibly facilitate the desirable therapeutic efficacy as a whole in ailments.
Literature survey reveals that guggulsterone E & Z from Commiphora mukul, piperine from Piper longum are responsible for anti-inflammatory activity whereas gallic acid from Terminalia chebula & Terminalia belerica & ascorbic acid from Emblica officinalis are responsible for its antioxidant activity.
Commiphora mukul: Guggulu is an exudates obtained in the form of oleogum resin from the stem of Commiphora mukul. It has analgesic & anti-inflammatory properties due to the presence of guggulsterone E & Z. Guggulsterone shows anti-inflammatory effect by inhibiting the activation of nuclear factor-kappa-B (NF-kappa-B).
Plumbago zeylanicum: Plumbago zeylanicum possesses flavonoids, which are known to inhibit the prostaglandins synthesis. Flavonoids of Plumbago zeylanicum help to reduce pain perception by suppressing pain substances like prostaglandins & bradykinin. It also controls excessive collagenase production. Study reveals that analgesic effect is comparable to that of Indomethacin.
Nigela sativa: Nigella sativa contains thymoquinone, which inhibits the effect of nociceptive system or inflammatory mediators and reduces pain. The anti-nociceptive effect of Nigella sativa is comparable with that of Naproxen.
Vanda Roxburghii: Vanda Roxburghii reduces pain & inflammation. Heptacosane & octacosan of Vanda roxburghii shows anti-inflammatory activity.
Zingiber officinale: Gingerol from Zingiber officinale possesses anti-inflammmatory and analgesic properties. This formulation inhibits production of prostaglandins & leukotrienes that are responsible for pain & inflammation.
The rock salt used in the short term performance of these plants helps. This herb acts as a carrier material.
Literature survey reveals that guggulsterone E & Z from Commiphora mukul, piperine from Piper longum are responsible for anti-inflammatory activity whereas gallic acid from Terminalia chebula & Terminalia belerica & ascorbic acid from Emblica officinalis are responsible for its antioxidant activity.
Commiphora mukul: Guggulu is an exudates obtained in the form of oleogum resin from the stem of Commiphora mukul. It has analgesic & anti-inflammatory properties due to the presence of guggulsterone E & Z. Guggulsterone shows anti-inflammatory effect by inhibiting the activation of nuclear factor-kappa-B (NF-kappa-B).
Plumbago zeylanicum: Plumbago zeylanicum possesses flavonoids, which are known to inhibit the prostaglandins synthesis. Flavonoids of Plumbago zeylanicum help to reduce pain perception by suppressing pain substances like prostaglandins & bradykinin. It also controls excessive collagenase production. Study reveals that analgesic effect is comparable to that of Indomethacin.
Nigela sativa: Nigella sativa contains thymoquinone, which inhibits the effect of nociceptive system or inflammatory mediators and reduces pain. The anti-nociceptive effect of Nigella sativa is comparable with that of Naproxen.
Vanda Roxburghii: Vanda Roxburghii reduces pain & inflammation. Heptacosane & octacosan of Vanda roxburghii shows anti-inflammatory activity.
Zingiber officinale: Gingerol from Zingiber officinale possesses anti-inflammmatory and analgesic properties. This formulation inhibits production of prostaglandins & leukotrienes that are responsible for pain & inflammation.
The rock salt used in the short term performance of these plants helps. This herb acts as a carrier material.
Dosage & Administration
One capsule 2-3 times a day after meals or as advised by the physician.
Interaction
Large amounts of guggulu might theoretically increase the side effects of estrogen; decrease the effectiveness of diltiazem. Taking guggulu along with some medications like atorvastatin, ketoconazole, itraconazole& fexofenadine that are broken down by the liver can decreases the effectiveness of medications. Guggulu might increase thyroid hormone in the body.Taking guggulu along with thyroid hormone pills might increase the effects & side effects of thyroid hormone.
Contraindications
Jogaraj guggulu is contraindicated in cases of known allergy to plants or guggulu. It is well tolerated but precaution should be taken in hyperthyroidism, diarrhea, during use of antihypertensive, anti-fungal & lipid lowering medication.
Side Effects
No severe side effects have been observed with Jogaraj guggulu during the clinical practice for the last twenty-five years; however, systematic Phase 1 study with this drug is carried out and general tolerability of Jogaraj guggulu is found good.Maximum tolerable dose is about 9 gm per day. In rare case very high dose than prescribed may lead to stomach irritation,diarrhea,stomatitis & urticaria.
Pregnancy & Lactation
Jogaraj guggulu should not be used during pregnancy or lactation.
Therapeutic Class
Herbal and Nutraceuticals
Storage Conditions
Keep in a cool,dry place & away from direct sun light.Keep the medicine out of children's reach.
