Acidic component (HCO3 Hemodialysis Solution)

Composition

Calcium Chloride 0.974 %
Glacial Acetic Acid 0.884 %
Magnessium Chloride 0.374 %
Potassium Chloride 0.55 %
Sodium Chloride 16.143 %

Indications

This solution is used in Haemodialysis.

Therapeutic Class

Haemodialysis solutions

Pharmacology

Calcium chloride is used to prevent or treat negative calcium balance. It also regulates action potential excitation threshold to facilitate nerve and muscle performance.

Potassium chloride is a major cation of the intracellular fluid. It plays an active role in the conduction of nerve impulses in the heart, brain and skeletal muscle; contraction of cardiac skeletal and smooth muscles; maintenance of normal renal function, acid-base balance, carbohydrate metabolism and gastric secretion.

Sodium chloride is the major extracellular cation. It is important in electrolyte and fluid balance, osmotic pressure control and water distribution as it restores sodium ions. It is used as a source of electrolytes and water for hydration, treatment of metabolic acidosis, priming solution in haemodialysis and treatment of hyperosmolar diabetes. It is also used as diluents for infusion of compatible drug additives.

Magnessium Chloride acts as cofactor in numerous enzymatic reactions involving protein synthesis and carbohydrate metabolism; depresses CNS, blocks peripheral neuromuscular transmission, produces anticonvulsant effects.

Dosage & Administration

Recommended dose: 5 liters concentrate per dialysis or as required.

Interaction

There are no known drug interactions and none well documented.

Contraindications

Known hypersensitivity to any of the ingredients of this preparation.

Side Effects

Fluid and electrolyte imbalance, hypovolemia, hypotension or muscle cramping may occur.

Pregnancy & Lactation

Pregnancy Category is not Classified. FDA has not yet classified the drug into a specified pregnancy category.

Precautions

It is used for hemodialysis purposes only. Do not use solution A or B alone. Discard container in case visible solid particles inside.