Undenatured Type II Collagen + Glucosamine sulfate + Boswellia serrata + Boron

Indications

This preparation is indicated in-
  • Osteoarthritis & rheumatoid arthritis
  • Difficulties in flexibility & mobility
  • Joint pain & inflammation
  • Joint discomfort & stiffness (knee extension)
  • Impaired joint function

Composition

Each tablet contains-
  • Undenatured Type II collagen 20 mg
  • Glucosamine sulfate 750 mg
  • Boswellia serrata 50 mg
  • Boron (Calcium fructoborate) 0.75 mg

Pharmacology

Undenatured Type II collagen (UC-II): Undenatured Type II collagen (UC-II) is a nutritional supplement derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity. UC-II has unique mechanism of action. UC-II molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of UC-II interact with Peyer’s patches (lymphoid tissue) of small intestine and it transforms T-cells into T- regulatory cells. T-regulatory cells then migrate to joint area and secrete anti-inflammatory mediators (cytokines), including the transforming growth factor-beta (TGF beta) and interleukin 10 (IL-10). Thus it reduces joint inflammation and promotes cartilage repair. According to ORSI (osteoarthritis research society international), oral administration of UC-II diminished deterioration of articular cartilage of osteoarthritis (OA).

Glucosamine sulfate: Glucosamine sulfate is a natural supplement. It is a sugar protein that helps build cartilage. Glucosamine, a normal constituent of glycosaminoglycans in cartilage matrix and synovial fluid, could have various pharmacological actions in articular cartilage and joint tissues. In randomized, placebo-controlled clinical trial, long-term administration of glucosamine sulfate can prevent joint structure changes in patients with osteoarthritis of the knee with a significant improvement in symptoms.

Boswellia serrata: This plant extract promotes joint health by inhibiting inflammatory factors such as the 5-lipoxygenase (5-LOX) enzyme and leukotriene B4, which affect aging joints. Extract of Boswellia serrata has been clinically studied for osteoarthritis, joint function & joint pain. Boswellia may also help reduce cartilage damage in arthritis. In a placebo-controlled clinical study, Boswellia extract improves signs of joint discomfort in just 8 weeks. Boswellia serrata as a promising alternative to NSAIDs.

Boron (calcium fructoborate): It is a patented complex of calcium, fructose & boron found naturally in fresh and dried fruits, vegetables and herbs. Calcium fructoborate significantly reduces the C-reactive protein in humans. This unique plant-mineral complex is contribute to bone health by controlling the inflammation associated with loss of bone mineral density.

Dosage & Administration

Adult dose: 1 tablet orally twice daily after meal. Or as directed by the physician.

Use in children & adolescents: Safety and effectiveness in children patients below 12 years of age have not been established.

Interaction

There have been no reports of significant drug Interactions of UC-II, Boswellia serrata, Glucosamine sulfate, Calcium fructoborate. But in case of Glucosamine sulfate & Boswellia serrata there are a chance of drug interaction with blood thinner medications (e,g warfarin & heparin).

Contraindications

Contraindicated in patients with known hypersensitivity to chicken, egg & shellfish.

Side Effects

The combination of Undenatured Type II collagen, Glucosamine, Boswellia & Boron is generally well-tolerated in the recommended dose. Overdose may cause headache & constipation.

Pregnancy & Lactation

Not recommended duration pregnancy and lactation.

Precautions & Warnings

No special studies were confirmed in patients with renal and/or hepatic insufficiency. However, administration to these patients with severe renal or hepatic insufficiency should be under appropriate medical supervision.

Overdose Effects

The signs and symptoms of overdose include nausea, vomiting, diarrhoea, constipation and abdominal discomfort.

Therapeutic Class

Specific mineral & vitamin combined preparations

Storage Conditions

Store below 30° C temperature & in dry place, protected from light. Keep out of the reach of children.

Available Brand Names