Aceclofenac

Prescribing Information (Research Brand)

Indications

Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Therapeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Pharmacology

Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins.

Dosage & Administration

Adults: 100 mg twice daily, one in the morning & one in the evening or 200 mg (one SR tablet) once daily.
Children: Not recommended.

Reduce the dosage to 100 mg daily initially in patients with hepatic dysfunction. There is no evidence that the dosage of aceclofenac needs to be modified in patients with mild renal impairment, but as with other NSAIDs caution should be exercised.

Interaction

Lithium and Digoxin: Aceclofenac, like many NSAIDs may increase plasma concentrations of lithium and Digoxin.

Diuretics: Aceclofenac, like other NSAIDs, may interact the activity of diuretics.

Anticoagulants: Like other NSAIDs, Aceclofenac may enhance the activity of anticoagulant. Close monitoring of patients on combined anticoagulants and Aceclofenac therapy should be undertaken.

Methotrexate: Caution should be exercised if NSAIDs and Methotrexate are administered within 24 hours of each other, since NSAIDs may increase Methotrexate plasma levels, resulting in increased toxicity.

Contraindications

Aceclofenac should not be administered to patients with active or suspected peptic ulcer or gastro-intestinal bleeding. It should not be given to patients with moderate to severe renal impairment. Close medical surveillance is also imperative in patients suffering from severe impairment of hepatic function. It should not be prescribed during pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used. Aceclofenac should not be administered to patients previously sensitive to Aceclofenac or in whom aspirin or NSAIDs precipitate attacks of asthma, acute rhinitis or urticaria or who are hypersensitive to these drugs.

Side Effects

The majority of side-effects observed have been reversible and of a minor nature and include gastro-intestinal disorders (dyspepsia, abdominal pain, nausea and diarrhea) and occasional occurrence of dizziness. Dermatological complaints including pruritus and rash and abnormal hepatic enzyme levels and raised serum creatinine have occasionally been reported.

Pregnancy & Lactation

The use of Aceclofenac should be avoided in pregnancy and lactation unless the potential benefits to the mother outweigh the possible risks to the fetus.

Precautions

Aceclofenac should not be administered to patients with active or suspected peptic ulcer or gastro-intestinal bleeding. It should not be given to patients with moderate to severe renal impairment. Close medical surveillance is also imperative in patients suffering from severe impairment of hepatic function. It should not be prescribed during pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used. Aceclofenac should not be administered to patients previously sensitive to Aceclofenac or in whom aspirin or NSAIDs precipitate attacks of asthma, acute rhinitis or urticaria or who are hypersensitive to these drugs.

Overdose Effects

There are no human data available on the consequences of Aceclofenac over dosage. If over dosage is observed, therapeutic measures should be taken according to symptoms; supportive and symptomatic treatment should be given for complications such as hypotension, gastro-intestinal irritation, respiratory depression, and convulsions.

Storage Conditions

Keep at a cool and dry place, protected from light and moisture.

Available Brand Names

  • A-Pak Tablet
    100 mg
    Benham Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Ac PR Tablet
    100 mg
    Pacific Pharmaceuticals Ltd.
    Unit Price : ৳ 4.00
  • Acebid Tablet
    100 mg
    Beacon Pharmaceuticals Ltd.
    Unit Price : ৳ 4.00
  • Aceclocil Tablet
    100 mg
    Pharmacil Limited
    Price not available
  • Aceclof Tablet
    100 mg
    Premier Pharmaceuticals Ltd.
    Price not available
  • Aceclofar Tablet
    100 mg
    Bengal drugs Ltd.
    Price not available
  • Aceclofen Tablet
    100 mg
    Astra Biopharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Aceclofenac Tablet
    100 mg
    Albion Pharmaceuticals Ltd.
    Unit Price : ৳ 2.50
  • Aceclora Tablet
    100 mg
    Marksman Pharmaceuticals Ltd.
    Unit Price : ৳ 1.90
  • Acecol Tablet
    100 mg
    Ziska Pharmaceuticals Ltd.
    Unit Price : ৳ 2.00
  • Acedol Tablet
    100 mg
    Concord Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Acedol SR Tablet (Sustained Release)
    200 mg
    Concord Pharmaceuticals Ltd.
    Unit Price : ৳ 7.00
  • Acefenac Tablet
    100 mg
    General Pharmaceuticals Ltd.
    Unit Price : ৳ 4.00
  • Acegic Tablet
    100 mg
    Belsen Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Acelock Tablet
    100 mg
    Bristol Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Acelon Tablet
    100 mg
    Central Pharmaceuticals Ltd (CPL)
    Unit Price : ৳ 3.00
  • Acenac Tablet
    100 mg
    Medicon Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Acenopan Tablet
    100 mg
    RN Pharmaceuticals
    Price not available
  • Acepro Tablet
    100 mg
    The White Horse Pharma
    Unit Price : ৳ 3.00
  • ACF Tablet
    100 mg
    Decent Pharma Laboratories Ltd.
    Unit Price : ৳ 4.00
  • Acflam Tablet
    100 mg
    Apollo Pharmaceutical Laboratories Ltd.
    Unit Price : ৳ 3.00
  • Aclo Tablet
    100 mg
    Alco Pharma Ltd.
    Unit Price : ৳ 3.00
  • Aclonac Tablet
    100 mg
    Pharmasia Ltd.
    Unit Price : ৳ 3.00
  • Aclopain Tablet
    100 mg
    Julphar Bangladesh Ltd.
    Unit Price : ৳ 4.00
  • Aclovix Tablet
    100 mg
    Aexim Pharmaceuticals Ltd.
    Unit Price : ৳ 2.50
  • ACN Tablet
    100 mg
    Modern Pharmaceuticals Limited
    Unit Price : ৳ 3.00
  • Alcefen Tablet
    100 mg
    Allied Pharmaceuticals Ltd.
    Unit Price : ৳ 4.00
  • Alofen Tablet
    100 mg
    Orbit Pharmaceuticals Ltd
    Unit Price : ৳ 3.00
  • Alona Tablet
    100 mg
    Kemiko Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Analgen Tablet
    100 mg
    Cosmo Pharma Laboratories Ltd.
    Unit Price : ৳ 3.00
  • Apeclo Tablet
    100 mg
    Apex Pharmaceuticals Ltd.
    Unit Price : ৳ 2.53
  • Apeclo SR Tablet (Sustained Release)
    200 mg
    Apex Pharmaceuticals Ltd.
    Unit Price : ৳ 5.00
  • Apitac Tablet
    100 mg
    Acme Laboratories Limited.
    Unit Price : ৳ 4.00
  • Aros Tablet
    100 mg
    Globe Pharmaceuticals Limited.
    Unit Price : ৳ 3.00
  • ASP Tablet
    100 mg
    Quality Pharmaceuticals (Pvt) Ltd.
    Price not available
  • Avenac Tablet
    100 mg
    Radiant Pharmaceuticals Ltd.
    Unit Price : ৳ 5.00
  • Biosnac Tablet
    100 mg
    Bios Pharmaceuticals Ltd.
    Price not available
  • Ceclofen Tablet
    100 mg
    Renata Limited
    Unit Price : ৳ 3.00
  • Ceclonac Tablet
    100 mg
    Oyster Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Ceconac Tablet
    100 mg
    Hudson Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Celofen Tablet
    100 mg
    ACI Limited.
    Unit Price : ৳ 4.01
  • Clof Tablet
    100 mg
    Biopharma Laboratories Ltd.
    Unit Price : ৳ 4.00
  • Clofenta Tablet
    100 mg
    Amico Laboratories Ltd.
    Unit Price : ৳ 2.50
  • Dolonac Tablet
    100 mg
    Cosmo Pharma Laboratories Ltd.
    Unit Price : ৳ 3.00
  • Ecena Tablet
    100 mg
    Edruc Ltd.
    Unit Price : ৳ 3.00
  • Ectinac Tablet
    100 mg
    Unimed Unihealth MFG. Ltd.
    Price not available
  • Ena Tablet
    100 mg
    Asiatic Laboratories Ltd.
    Unit Price : ৳ 3.00
  • Exipain Tablet
    100 mg
    Opso Saline Ltd.
    Price not available
  • Ezemove Tablet
    100 mg
    Globex Pharmaceuticals Ltd.
    Unit Price : ৳ 4.00
  • Fenaaf Tablet
    100 mg
    Naafco Pharma Ltd.
    Price not available
  • Fenacin Tablet
    100 mg
    Nipa Pharmaceuticals Ltd.
    Price not available
  • Fixonac Tablet
    100 mg
    Euro Pharma Ltd.
    Unit Price : ৳ 3.00
  • Fleco Tablet
    100 mg
    Ad-din pharmaceuticals Ltd.
    Unit Price : ৳ 2.50
  • Flexi Tablet
    100 mg
    Square Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Flexi SR Tablet (Extended Release)
    200 mg
    Square Pharmaceuticals Ltd.
    Unit Price : ৳ 7.02
  • Flexidol Tablet
    100 mg
    Social Marketing Company
    Unit Price : ৳ 3.00
  • Flexivan Tablet
    100 mg
    NIPRO JMI Pharma Ltd.
    Unit Price : ৳ 4.01
  • Flexivan ER Tablet (Extended Release)
    200 mg
    NIPRO JMI Pharma Ltd.
    Unit Price : ৳ 6.02
  • Freemax Tablet
    100 mg
    Nuvista Pharma Ltd.
    Unit Price : ৳ 4.96
  • Grofenac Tablet
    100 mg
    Prime Pharmaceuticals Ltd.
    Price not available
  • Hifenac Tablet
    100 mg
    Doctor TIMS Pharmaceuticals Ltd.
    Unit Price : ৳ 2.50
  • Intas Tablet
    100 mg
    Virgo Pharmaceuticals Ltd.
    Unit Price : ৳ 3.50
  • Labenac Tablet
    100 mg
    Labaid Pharma Ltd.
    Unit Price : ৳ 4.50
  • Lofam Tablet
    100 mg
    Millat Pharmaceuticals Limited
    Unit Price : ৳ 3.00
  • Lofens Tablet
    100 mg
    Zenith Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Maxpain Tablet
    100 mg
    Guardian Healthcare Ltd
    Unit Price : ৳ 3.50
  • Mervan Tablet
    100 mg
    Aristopharma Ltd.
    Unit Price : ৳ 4.00
  • Mervan SR Tablet (Sustained Release)
    200 mg
    Aristopharma Ltd.
    Price Unavailable
  • Motifen Tablet
    100 mg
    Pharmadesh Laboratories Ltd.
    Unit Price : ৳ 3.50
  • Movex Tablet
    100 mg
    Opsonin Pharma Ltd.
    Unit Price : ৳ 3.00
  • Movex SR Tablet (Sustained Release)
    200 mg
    Opsonin Pharma Ltd.
    Price not available
  • Movon Tablet
    100 mg
    Hallmark Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Noak Tablet
    100 mg
    Orion Pharma Ltd.
    Unit Price : ৳ 3.00
  • Nofenac Tablet
    100 mg
    Drug International Ltd.
    Unit Price : ৳ 4.00
  • Nostrin Tablet
    100 mg
    Monicopharma Limited
    Unit Price : ৳ 3.00
  • Orcenac Tablet
    100 mg
    Organic Health Care
    Unit Price : ৳ 4.00
  • Orifen Tablet
    100 mg
    Silva Pharmaceuticals Ltd.
    Unit Price : ৳ 2.50
  • Ostoflex Tablet
    100 mg
    Somatec Pharmaceuticals Ltd.
    Unit Price : ৳ 4.00
  • Painex Tablet
    100 mg
    Chemist Laboratories Limited.
    Unit Price : ৳ 3.00
  • Painkil Tablet
    100 mg
    Veritas Pharmaceuticals Ltd.
    Unit Price : ৳ 4.02
  • Paino Tablet
    100 mg
    Eskayef Bangladesh Ltd.
    Unit Price : ৳ 4.00
  • Pankil Tablet
    100 mg
    Everest Pharmaceuticals Ltd.
    Unit Price : ৳ 2.50
  • Penac- AC Tablet
    100 mg
    APC Pharma Ltd.
    Unit Price : ৳ 3.00
  • Phoenix Aceclofance Tablet
    100 mg
    Phoenix Chemicals Laboratory (BD) Ltd
    Price not available
  • Pkil Tablet
    100 mg
    National Laboratories Ltd.
    Price not available
  • Polynac Tablet
    100 mg
    Leon Pharmaceuticals Ltd.
    Unit Price : ৳ 4.01
  • Ponos Tablet
    100 mg
    One Pharma Ltd.
    Price not available
  • Preservin 100 Tablet
    100 mg
    Ibn-Sina Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Preservin SR Tablet (Sustained Release)
    200 mg
    Ibn-Sina Pharmaceuticals Ltd.
    Unit Price : ৳ 7.00
  • Protilez Tablet
    100 mg
    Reliance Pharmaceuticals Ltd.
    Unit Price : ৳ 4.00
  • Rapid Tablet
    100 mg
    Innova Pharmaceuticals Limited.
    Price not available
  • Relise Tablet
    100 mg
    Indo Bangla Pharmaceutical
    Unit Price : ৳ 2.50
  • Repidor Tablet
    100 mg
    Rephco Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Reservix Tablet
    100 mg
    Incepta Pharmaceuticals Limited
    Unit Price : ৳ 4.00
  • Reservix SR Tablet (Sustained Release)
    200 mg
    Incepta Pharmaceuticals Limited
    Unit Price : ৳ 7.00
  • Rheuma Tablet
    100 mg
    Mystic Pharmaceuticals Ltd.
    Unit Price : ৳ 2.80
  • Rheunil Tablet
    100 mg
    Amulet Pharmaceuticals Ltd.
    Unit Price : ৳ 3.01
  • Roa Tablet
    100 mg
    Standard Laboratories Limited
    Price not available
  • Ruclon Tablet
    100 mg
    Novus Pharmaceuticals Ltd.
    Price not available
  • Rumac Tablet
    100 mg
    Sonear Laboratories Ltd.
    Price not available
  • Sapclo Tablet
    100 mg
    Shamsul Al-Amin Pharmaceutical Ltd.
    Unit Price : ৳ 3.00
  • Senac-A Tablet
    100 mg
    Seba Laboratories Ltd.
    Price not available
  • Servex Tablet
    100 mg
    Novo Healthcare and Pharma Ltd.
    Unit Price : ৳ 4.00
  • Silfenac Tablet
    100 mg
    Silco Pharmaceutical Ltd.
    Price not available
  • Syclofen Tablet
    100 mg
    MST Pharma
    Unit Price : ৳ 3.00
  • Technofen Tablet
    100 mg
    Techno Drugs Ltd.
    Price not available
  • Tek Tablet
    100 mg
    Team Pharmaceuticals Ltd.
    Price not available
  • Ternilla Tablet
    100 mg
    Healthcare Pharmacuticals Ltd.
    Unit Price : ৳ 4.00
  • Tuffox Tablet
    100 mg
    Eskayef Bangladesh Ltd.
    Unit Price : ৳ 3.00
  • Vaxtin Tablet
    100 mg
    Novartis (Bangladesh) Ltd.
    Unit Price : ৳ 5.00
  • Volfenac Tablet
    100 mg
    S.N. Pharmaceutical Ltd.
    Unit Price : ৳ 3.00
  • Xa Fast Tablet
    100 mg
    Desh Pharmaceuticals Ltd.
    Unit Price : ৳ 2.50
  • Xerifen Tablet
    100 mg
    Peoples Pharma Ltd.
    Unit Price : ৳ 3.00
  • Xeriflam Tablet
    100 mg
    Kumudini Pharma Ltd.
    Unit Price : ৳ 3.00
  • Xpain Tablet
    100 mg
    Gaco Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Xtrafen Tablet
    100 mg
    Delta Pharma Limited
    Unit Price : ৳ 2.00
  • Xtrafen SR Tablet (Sustained Release)
    200 mg
    Delta Pharma Limited
    Price not available
  • Xyfen Tablet
    100 mg
    Supreme Pharmaceutical Ltd.
    Unit Price : ৳ 3.00
  • Zerodol Tablet
    100 mg
    Navana Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Zolfin Tablet
    100 mg
    Beximco Pharmaceuticals Ltd.
    Unit Price : ৳ 3.00
  • Zolonac Tablet
    100 mg
    Sharif Pharmaceuticals Ltd.
    Unit Price : ৳ 4.00