Bicarbonate Component [HCO3 Hemodialysis Solution]

Composition

Each 1 liter solution contains-
  • Sodium Chloride: 30.5 gm
  • Sodium bicarbonate: 66 gm
  • Highly purified water: q.s. to 1 liter

Indications

Bicarbonate Component [HCO3 Hemodialysis Solution] solution is indicated in renal failure, Chronic renal failure and Haemodialysis. Bicarbonate serves a crucial biochemical role in the physiological pH buffering system.

Pharmacology

Sodium chloride is the major extracellular cation. It is important in electrolyte and fluid balance, osmotic pressure control and water distribution as it restores sodium ions. It is used as a source of electrolytes and water for hydration, treatment of metabolic acidosis, priming solution in haemodialysis and treatment of hyperosmolar diabetes. It is also used as diluents for infusion of compatible drug additives. Sodium bicarbonate raises blood and urinary pH by dissociation to provide bicarbonate ions, which neutralises the hydrogen ion concentration. It also neutralises gastric acid via production of carbon dioxide.

Dosage & Administration

Acidic component & Bicarbonate Component should be used in the dilution ratio of-
  • Acidic component: 1.00 Volume
  • Bicarbonate Component: 1.83 Volume
  • Purified Water: 34.00 Volume

Interaction

Sodium bicarbonate: Increases toxicity of amphetamines, ephedrine, pseudoephedrine, flecainide, quinidine and quinine. Decreases effects of lithium, chlorpropamide and salicylates due to increased clearance. May affect the absorption of certain drugs due to raised intra-gastric pH. Sodium chloride: May affect serum concentrations of lithium.

Contraindications

Known hypersensitivity to any of the ingredients of this preparation.

Precautions & Warnings

  • Bicarbonate Component needs to be used with Acidic component (not to be used alone).
  • Before use, the mixed solution must be diluted with
  • highly purified water.
  • Close the container tightly immediately after use.
  • Discard solution in case of visible solid particles inside.
  • Discard solution after 96 hours of first opening.

Therapeutic Class

Haemodialysis solutions

Storage Conditions

Keep out of reach of children. Not for Injection. Store below 30°C.