3-Geocef Powder for Suspension

100 mg/5 ml
Hallmark Pharmaceuticals Ltd.

Pack Size & Price:

50 ml bottle : ৳ 175.00

Indications

Cefixime is indicated in the following infectious diseases-
  • Respiratory Tract Infections: Pneumonia, Sinusitis, Pharyngitis and Tonsillitis, Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis (AECB)
  • Otitis Media 
  • Typhoid
  • Urinary Tract Infections
  • Uncomplicated gonorrhea (cervical/urethral).

Therapeutic Class

Third generation Cephalosporins

Pharmacology

Cefixime binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Dosage & Administration

The usual course of treatment is 7 days. This may be continued for up to 14 days if required. The daily dose can be given in 1–2 divided doses.

Usual dose:
  • Adult and child over 10 years: 200–400 mg daily
  • Child over 6 months: 8 mg/kg daily
  • 6 months to 1 year: 75 mg (3.75 ml) daily,
  • 1 to 4 years: 100 mg (5 ml) daily
  • 5 to 10 years: 200 mg (10 ml) daily
Typhoid and paratyphoid :
  • Adult: 200 mg 12 hourly
  • Child: 10 mg/kg 12 hourly
Gonorrhoea:
  • Adult: 400-800 mg as a single dose

Interaction

Increased prothrombin time (with or withot bleeding) with anticoagulants (e.g. warfarin). Increased plasma carbamazepine concentrations with concomitant use. Increased bioavailability with nifedipine. Increased serum concentration with probenecid.

Contraindications

Patients with known hypersensitivity to cephalosporin antibiotics, children under 6 months.

Side Effects

Cefixime is generally well tolerated. The majority of side-effects observed in clinical trials were mild and self-limiting in nature. Diarrhoea, stool changes, nausea, vomiting, abdominal pain, dyspepsia, headache and dizziness.

Pregnancy & Lactation

Pregnancy category B. There are no adequate and well-controlled studies in pregnant women. So this drug should be used during pregnancy only if clearly needed.

Use in Lactation: It is not known whether cefixime is excreted in human milk. So it is probably best either to avoid using the drug by the nursing mother or to discontinue breast feeding.

Precautions

Patient with history of penicillin allergy. Renal impairment. Children. Pregnancy and lactation.

Overdose Effects

Symptoms: Mild to moderate adverse GI effects.
Management: Supportive treatment. Empty stomach by gastric lavage.

Use in Special Population

Use in Children: Safety and effectiveness of cefixime in children aged less than 6 months have not been established. For children younger than 12 years or weighing less than 50 kg, the usual dose is 8 mg/kg/day.

Use in elderly:  No special precautions are necessary. Old age is not an indication for dose adjustment.

Dosage in renal impairment:
  • Creatinine clearance: 20 ml/min or greater: normal dose
  • Creatinine clearance: <20 ml/min or chronic ambulatory peritoneal dialysis
  • Haemodialysis: daily dose should not exceed 200 mg.

Storage Conditions

Store in a cool and dry place below 30ºC