Indications

Hysomide is an anticholinergic drug with an antispasmodic action on the smooth muscles of various organs in the abdominal cavity.
  • Tablets: Indicated for the relief of symptoms caused by visceral spasms in the gastrointestinal tract or genitourinary tract. It is also indicated for spasmodic dysmenorrhea (painful periods).
  • Injections: Indicated for acute spasms of the gastrointestinal tract, as well as severe renal (kidney) or biliary (gallbladder) colic.
  • Diagnostic Use: Hysomide injection is used to relieve spasms during diagnostic and radiological procedures, such as differential diagnosis of obstruction, reducing spasm and pain in pyelography, and during gastro-duodenal endoscopy.

Dosage & Administration

Oral-
  • Adults: 20 mg, four times a day. For spasmodic dysmenorrhea, treatment should ideally begin at least two days before the expected start of menstruation and continue for up to three days after the period starts.
  • Children (6 to 12 years): 10 mg, three times a day, or as directed by a physician.
Injection-
  • Adults (Intramuscular or Intravenous): The usual dose is 20 mg (1 ampoule). If necessary, this dose can be repeated after 30 minutes. During endoscopy, this dose may need to be administered more frequently.

Contraindications

This medication is contraindicated (should not be used) in patients with:
  • Prostatic enlargement (BPH). It must be used with caution in elderly patients.
  • Paralytic ileus or pyloric stenosis.
  • Glaucoma, due to the risk of mydriatic damage (increased pressure inside the eye).

Side Effects

The side effects of Hysomide include:
  • Dry mouth and dry skin.
  • Pupil dilation (mydriasis) and increased intraocular pressure.
  • Flushing.
  • Bradycardia (slow heart rate) followed by tachycardia (fast heart rate) and arrhythmia (irregular heartbeat).
  • Occasionally, fatigue, vomiting, giddiness (dizziness), and staggering may occur.

Pregnancy & Lactation

Like all other medications, it should be used with caution during the first trimester (first three months) of pregnancy.

Precautions & Warnings

Precautions: Hysomide can cause drowsiness and decrease mental alertness. Patients undergoing treatment with Hysomide should not drive, operate vehicles, or handle machinery where a lack of mental focus could cause accidents. Patients should also abstain from consuming alcohol.

Warnings:
  • Cardiovascular Conditions: Caution should be exercised in conditions like thyrotoxicosis, cardiac insufficiency or failure, and cardiac surgery, as Hysomide can further increase the heart rate.
  • Drug Interactions: Concurrent administration with other anticholinergic drugs—such as amantadine, certain antihistamines, butyrophenones, phenothiazines, and tricyclic antidepressants—may enhance the effect of Hysomide. In such cases, the dosage of Hysomide may need to be reduced.

Therapeutic Class

Anticholinergics (antimuscarinics)/ Anti-spasmodics

Reconstitution

Hysomide injection can be diluted with Dextran or 0.9% Sodium Chloride (Normal Saline) injection fluids.

Storage Conditions

Do not use after the expiration date. Keep all medicines out of the reach of children. To be dispensed only by the prescription of a registered physician.
Pack Image of Hysomide 20 mg/ml Injection Pack Image: Hysomide 20 mg/ml Injection
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